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所有(动物)神经退行性变模型都是错误的。它们还有用吗?

All (animal) models (of neurodegeneration) are wrong. Are they also useful?

机构信息

Third Rock Ventures, Boston, MA

Department of Cell Biology, Harvard Medical School, Boston, MA.

出版信息

J Exp Med. 2018 Dec 3;215(12):2955-2958. doi: 10.1084/jem.20182042. Epub 2018 Nov 20.

Abstract

Richard M. Ransohoff, Entrepreneur-in-Residence at Third Rock Ventures and Visiting Scientist at Harvard Medical School, provides his personal opinion on using animal models to address current challenges and opportunities in drug development for neurodegeneration.

摘要

理查德·兰索霍夫(Richard M. Ransohoff),Third Rock Ventures 的常驻企业家和哈佛医学院客座科学家,就利用动物模型解决神经退行性疾病药物开发中当前面临的挑战和机遇提供了个人观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99df/6279414/f5257ad04b07/JEM_20182042_Fig1.jpg

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