• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

所有（动物）神经退行性变模型都是错误的。它们还有用吗？

All (animal) models (of neurodegeneration) are wrong. Are they also useful?

机构信息

Third Rock Ventures, Boston, MA

Department of Cell Biology, Harvard Medical School, Boston, MA.

出版信息

J Exp Med. 2018 Dec 3;215(12):2955-2958. doi: 10.1084/jem.20182042. Epub 2018 Nov 20.

DOI:10.1084/jem.20182042
PMID:30459159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6279414/
Abstract

Richard M. Ransohoff, Entrepreneur-in-Residence at Third Rock Ventures and Visiting Scientist at Harvard Medical School, provides his personal opinion on using animal models to address current challenges and opportunities in drug development for neurodegeneration.

摘要

理查德·兰索霍夫（Richard M. Ransohoff），Third Rock Ventures 的常驻企业家和哈佛医学院客座科学家，就利用动物模型解决神经退行性疾病药物开发中当前面临的挑战和机遇提供了个人观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99df/6279414/f5257ad04b07/JEM_20182042_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99df/6279414/f5257ad04b07/JEM_20182042_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99df/6279414/f5257ad04b07/JEM_20182042_Fig1.jpg

相似文献

1
All (animal) models (of neurodegeneration) are wrong. Are they also useful?所有（动物）神经退行性变模型都是错误的。它们还有用吗？
J Exp Med. 2018 Dec 3;215(12):2955-2958. doi: 10.1084/jem.20182042. Epub 2018 Nov 20.
2
Biochemical, cellular and behavioural aspects of neurodegeneration: the view from down under.神经退行性变的生化、细胞及行为学方面：来自南半球的观点。
Neurotox Res. 2005;7(1-2):1-3. doi: 10.1007/BF03033771.
3
Protein aggregation and neurodegeneration.蛋白质聚集与神经退行性变。
Methods. 2011 Mar;53(3):185-6. doi: 10.1016/j.ymeth.2011.02.009.
4
Can neurodegeneration be separated from neuropathological hallmarks of chronic idiopathic human neurodegenerative disease? A perspective from modelling!神经退行性变能否与慢性特发性人类神经退行性疾病的神经病理学特征分离？建模视角！
Biochem Soc Trans. 2011 Aug;39(4):917-9. doi: 10.1042/BST0390917.
5
ROCK inhibition in models of neurodegeneration and its potential for clinical translation.神经退行性疾病模型中的 ROCK 抑制及其临床转化的潜力。
Pharmacol Ther. 2018 Sep;189:1-21. doi: 10.1016/j.pharmthera.2018.03.008. Epub 2018 Apr 3.
6
Drosophila models of neurodegenerative diseases.神经退行性疾病的果蝇模型
Annu Rev Pathol. 2009;4:315-42. doi: 10.1146/annurev.pathol.3.121806.151529.
7
Therapeutic role of sirtuins in neurodegenerative disease.沉默调节蛋白在神经退行性疾病中的治疗作用。
Biochim Biophys Acta. 2008 Jun;1782(6):363-9. doi: 10.1016/j.bbadis.2008.02.010. Epub 2008 Mar 7.
8
Autophagy in neurodegeneration and aging.神经退行性变与衰老中的自噬
Aging (Albany NY). 2018 Nov 14;10(12):3632-3633. doi: 10.18632/aging.101652.
9
Oxidative stress in neurodegeneration: cause or consequence?神经退行性变中的氧化应激：原因还是结果？
Nat Med. 2004 Jul;10 Suppl:S18-25. doi: 10.1038/nrn1434.
10
Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans.神经退行性疾病：秀丽隐杆线虫的启示。
Neurobiol Dis. 2010 Oct;40(1):4-11. doi: 10.1016/j.nbd.2010.05.012. Epub 2010 May 19.

引用本文的文献

1
Ideal animal models according to multifaceted mechanisms and peculiarities in neurological disorders: present and challenges.基于神经疾病多方面机制和特点的理想动物模型：现状与挑战
Arch Pharm Res. 2025 Jan;48(1):62-88. doi: 10.1007/s12272-024-01527-9. Epub 2024 Dec 18.
2
Animal models in neuroscience with alternative approaches: Evolutionary, biomedical, and ethical perspectives.神经科学中采用替代方法的动物模型：进化、生物医学和伦理视角。
Animal Model Exp Med. 2024 Dec;7(6):868-880. doi: 10.1002/ame2.12487. Epub 2024 Oct 7.
3
Characterization of brain transduction capability of a BBB-penetrant AAV vector in mice, rats and macaques reveals differences in expression profiles.

本文引用的文献

1
Alzheimer's disease drug development pipeline: 2018.2018年阿尔茨海默病药物研发进展
Alzheimers Dement (N Y). 2018 May 3;4:195-214. doi: 10.1016/j.trci.2018.03.009. eCollection 2018.
2
Clinical Trials for Disease-Modifying Therapies in Alzheimer's Disease: A Primer, Lessons Learned, and a Blueprint for the Future.阿尔茨海默病的疾病修饰治疗临床试验：入门、经验教训和未来蓝图。
J Alzheimers Dis. 2018;64(s1):S3-S22. doi: 10.3233/JAD-179901.
3
A mathematical model of multisite phosphorylation of tau protein.tau蛋白多位点磷酸化的数学模型。
在小鼠、大鼠和食蟹猴中对穿透 BBB 的 AAV 载体的脑内转导能力进行特征分析，揭示了表达谱的差异。
Gene Ther. 2024 Sep;31(9-10):455-466. doi: 10.1038/s41434-024-00466-w. Epub 2024 Jul 22.
4
Neuroinflammation in Neurodegenerative Disorders: Current Knowledge and Therapeutic Implications.神经退行性疾病中的神经炎症：当前的认识和治疗意义。
Int J Mol Sci. 2024 Apr 3;25(7):3995. doi: 10.3390/ijms25073995.
5
Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing.新型方法在发育和成年神经毒性测试中的最新进展和当前挑战。
Arch Toxicol. 2024 May;98(5):1271-1295. doi: 10.1007/s00204-024-03703-8. Epub 2024 Mar 13.
6
Recapitulating and reversing human brain ribosomopathy defects via the maladaptive integrated stress response.通过适应性综合应激反应重述和逆转人类大脑核糖体病缺陷。
Sci Adv. 2024 Feb 2;10(5):eadk1034. doi: 10.1126/sciadv.adk1034.
7
In depth characterization of midbrain organoids derived from wild type iPSC lines.对源自野生型诱导多能干细胞系的中脑类器官进行深入表征。
PLoS One. 2023 Oct 20;18(10):e0292926. doi: 10.1371/journal.pone.0292926. eCollection 2023.
8
Senolytic and senomorphic secondary metabolites as therapeutic agents in models of Parkinson's disease.作为帕金森病模型治疗药物的溶酶体衰老清除剂和衰老形态调节剂次级代谢产物
Front Neurol. 2023 Sep 28;14:1271941. doi: 10.3389/fneur.2023.1271941. eCollection 2023.
9
Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia.在额颞叶痴呆的CRISPR基因编辑多能干细胞模型中星形胶质细胞功能障碍与神经网络活动亢进
Brain Commun. 2023 May 18;5(3):fcad158. doi: 10.1093/braincomms/fcad158. eCollection 2023.
10
Functional bioengineered tissue models of neurodegenerative diseases.神经退行性疾病的功能生物工程组织模型。
Biomaterials. 2023 Jul;298:122143. doi: 10.1016/j.biomaterials.2023.122143. Epub 2023 May 2.
PLoS One. 2018 Feb 6;13(2):e0192519. doi: 10.1371/journal.pone.0192519. eCollection 2018.
4
APP mouse models for Alzheimer's disease preclinical studies.用于阿尔茨海默病临床前研究的APP小鼠模型。
EMBO J. 2017 Sep 1;36(17):2473-2487. doi: 10.15252/embj.201797397. Epub 2017 Aug 1.
5
An environment-dependent transcriptional network specifies human microglia identity.一个依赖环境的转录网络决定了人类小胶质细胞的特性。
Science. 2017 Jun 23;356(6344). doi: 10.1126/science.aal3222. Epub 2017 May 25.
6
Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice.来自阿尔茨海默病大脑的独特病理性tau构象在非转基因小鼠中传播tau病理。
J Exp Med. 2016 Nov 14;213(12):2635-2654. doi: 10.1084/jem.20160833. Epub 2016 Oct 17.
7
The support of human genetic evidence for approved drug indications.支持人类遗传证据用于批准的药物适应证。
Nat Genet. 2015 Aug;47(8):856-60. doi: 10.1038/ng.3314. Epub 2015 Jun 29.
8
Spreading of pathology in neurodegenerative diseases: a focus on human studies.神经退行性疾病中病理变化的传播：聚焦于人体研究。
Nat Rev Neurosci. 2015 Feb;16(2):109-20. doi: 10.1038/nrn3887. Epub 2015 Jan 15.
9
Alzheimer's disease risk genes and mechanisms of disease pathogenesis.阿尔茨海默病风险基因与疾病发病机制
Biol Psychiatry. 2015 Jan 1;77(1):43-51. doi: 10.1016/j.biopsych.2014.05.006. Epub 2014 May 17.
10
Evaluation of excess significance bias in animal studies of neurological diseases.神经病学疾病动物研究中过度显著偏倚的评估。
PLoS Biol. 2013 Jul;11(7):e1001609. doi: 10.1371/journal.pbio.1001609. Epub 2013 Jul 16.