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血管内支架在磁共振成像期间的射频安全性评估

Radio-Frequency Safety Assessment of Stents in Blood Vessels During Magnetic Resonance Imaging.

作者信息

Fujimoto Kyoko, Angelone Leonardo M, Lucano Elena, Rajan Sunder S, Iacono Maria Ida

机构信息

Division of Biomedical Physics, Office of Science and Engineering Laboratory, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, United States.

出版信息

Front Physiol. 2018 Oct 22;9:1439. doi: 10.3389/fphys.2018.01439. eCollection 2018.

Abstract

The purpose of this study was to investigate the need for high-resolution detailed anatomical modeling to correctly estimate radio-frequency (RF) safety during magnetic resonance imaging (MRI). RF-induced heating near metallic implanted devices depends on the electric field tangential to the device ( ). and specific absorption rate (SAR) were analyzed in blood vessels of an anatomical model to understand if a standard gel phantom accurately represents the potential heating in tissues due to passive vascular implants such as stents. A numerical model of an RF birdcage body coil and an anatomically realistic virtual patient with a native spatial resolution of 1 mm were used to simulate the electric field at 64 MHz (1.5 T MRI system). Maximum values of SAR inside the blood vessels were calculated and compared with peaks in a numerical model of the ASTM gel phantom to see if the results from the simplified and homogeneous gel phantom were comparable to the results from the anatomical model. values were also calculated in selected stent trajectories inside blood vessels and compared with the ASTM result. Peak SAR values in blood vessels were up to ten times higher than those found in the ASTM standard gel phantom. Peaks were found in clinically significant anatomical locations, where stents are implanted as per intended use. Furthermore, results showed that volume-averaged SAR values might not be sufficient to assess RF safety. Computational modeling with a high-resolution anatomical model indicated higher values of the incident electric field compared to the standard testing approach. Further investigation will help develop a robust safety testing method which reflects clinically realistic conditions.

摘要

本研究的目的是调查是否需要高分辨率的详细解剖模型,以在磁共振成像(MRI)期间正确估计射频(RF)安全性。金属植入装置附近的射频感应加热取决于与装置相切的电场( )。在一个解剖模型的血管中分析了 和比吸收率(SAR),以了解标准凝胶体模是否能准确代表由于支架等被动血管植入物而在组织中产生的潜在加热。使用一个射频鸟笼体线圈的数值模型和一个具有 1 毫米原生空间分辨率的解剖学逼真的虚拟患者来模拟 64 兆赫(1.5T MRI 系统)时的电场。计算血管内 SAR 的最大值,并与 ASTM 凝胶体模数值模型中的峰值进行比较,以查看简化且均匀的凝胶体模的结果是否与解剖模型的结果具有可比性。还计算了血管内选定支架轨迹处的 值,并与 ASTM 结果进行比较。血管中的 SAR 峰值比 ASTM 标准凝胶体模中的峰值高出多达十倍。在临床上重要的解剖位置发现了峰值,这些位置按预期用途植入了支架。此外, 结果表明,体积平均 SAR 值可能不足以评估 RF 安全性。与标准测试方法相比,使用高分辨率解剖模型的计算建模表明入射电场的值更高。进一步的研究将有助于开发一种反映临床实际情况的可靠安全测试方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af3c/6232906/fe2d85c235c5/fphys-09-01439-g001.jpg

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