Zhou Mian, Wang Wei
Department of Plant Pathology and Microbiology, Iowa State University, Ames, IA, United States.
School of Life Sciences, Peking University, Beijing, China.
Front Plant Sci. 2018 Nov 6;9:1613. doi: 10.3389/fpls.2018.01613. eCollection 2018.
Different from the conventional biocidal agrochemicals, synthetic chemical inducers of plant immunity activate, bolster, or prime plant defense machineries rather than directly acting on the pathogens. Advances in combinatorial synthesis and high-throughput screening methods have led to the discovery of various synthetic plant immune activators as well as priming agents. The availability of their structures and recent progress in the mechanistic understanding of plant immune responses have opened up the possibility of identifying new or more potent chemical inducers through rational design. In this review, we first summarize the chemical inducers identified through large-scale screening and then discuss the emerging trends in the identification and development of novel plant immune inducers including natural elicitor based chemical derivation, bifunctional combination, and computer-aided design.
与传统的杀生性农用化学品不同，植物免疫的合成化学诱导剂激活、增强或启动植物防御机制，而不是直接作用于病原体。组合合成和高通量筛选方法的进展导致发现了各种合成植物免疫激活剂以及启动剂。它们的结构信息以及植物免疫反应机制理解方面的最新进展为通过合理设计鉴定新的或更有效的化学诱导剂提供了可能性。在本综述中，我们首先总结通过大规模筛选鉴定出的化学诱导剂，然后讨论新型植物免疫诱导剂鉴定与开发的新趋势，包括基于天然激发子的化学衍生、双功能组合和计算机辅助设计。
