Mozaffari Sanam, Jaedicke Volker, LaRocca Francesco, Tiruveedhula Pavan, Roorda Austin
School of Optometry and Vision Science Graduate Group, University of California Berkeley, Berkeley, CA, USA.
Contributed equally to this work.
Biomed Opt Express. 2018 Oct 16;9(11):5477-5488. doi: 10.1364/BOE.9.005477. eCollection 2018 Nov 1.
Adaptive optics scanning laser ophthalmoscopy (AOSLO) is a powerful tool for imaging the retina at high spatial and temporal resolution. In this paper, we present a multi-detector scheme for AOSLO which has two main configurations: pixel reassignment and offset aperture imaging. In this detection scheme, the single element detector of the standard AOSLO is replaced by a fiber bundle which couples the detected light into multiple detectors. The pixel reassignment configuration enables high resolution imaging with an increased light collection. The increase in signal-to-noise ratio (SNR) from this configuration can improve the accuracy of motion registration techniques. The offset aperture imaging configuration enhances the detection of multiply scattered light, which improves the contrast of retinal vasculature and inner retinal layers similar to methods such as nonconfocal split-detector imaging and multi-offset aperture imaging.
自适应光学扫描激光检眼镜（AOSLO）是一种用于以高空间和时间分辨率对视网膜成像的强大工具。在本文中，我们提出了一种用于AOSLO的多探测器方案，该方案有两种主要配置：像素重新分配和偏移孔径成像。在这种检测方案中，标准AOSLO的单元素探测器被一个光纤束取代，该光纤束将检测到的光耦合到多个探测器中。像素重新分配配置能够在增加光收集的情况下进行高分辨率成像。这种配置下信噪比（SNR）的提高可以提高运动配准技术的准确性。偏移孔径成像配置增强了对多次散射光的检测，这类似于非共焦分裂探测器成像和多偏移孔径成像等方法，提高了视网膜血管系统和视网膜内层的对比度。
