可见光光学相干断层扫描揭示的啮齿动物视网膜循环组织与氧代谢
Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography.
作者信息
Pi Shaohua, Camino Acner, Wei Xiang, Simonett Joseph, Cepurna William, Huang David, Morrison John C, Jia Yali
机构信息
Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
出版信息
Biomed Opt Express. 2018 Oct 30;9(11):5851-5862. doi: 10.1364/BOE.9.005851. eCollection 2018 Nov 1.
Abstract
Visible light optical coherence tomography (vis-OCT) is an emerging label-free and high-resolution 3-dimensional imaging technique that can provide retinal oximetry, angiography, and flowmetry in one modality. In this paper, we studied the organization of the arterial and venous retinal circulation in rats using vis-OCT. Arterioles were found predominantly in the superficial vascular plexus whereas veins tended to drain capillaries from the deep capillary plexus. After that, we determined the oxygen metabolic rate supported by retinal microcirculation by combining retinal vessel oxygen saturation and blood flow measurements. The ability to visualize and monitor retinal circulation organization and oxygen metabolism by vis-OCT may provide new opportunities for understanding the pathology of ocular diseases.
摘要
可见光光学相干断层扫描（vis - OCT）是一种新兴的无标记高分辨率三维成像技术，它能够在一种模式下提供视网膜血氧测定、血管造影和血流测量。在本文中，我们使用vis - OCT研究了大鼠视网膜动静脉循环的组织结构。小动脉主要位于浅表血管丛，而静脉则倾向于引流来自深层毛细血管丛的毛细血管。之后，我们通过结合视网膜血管氧饱和度和血流测量来确定视网膜微循环支持的氧代谢率。通过vis - OCT可视化和监测视网膜循环组织及氧代谢的能力，可能为理解眼部疾病的病理学提供新的机会。
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