Hackett R A, Huang T W, Berger R E
Department of Urology, Seattle Veterans Administration Medical Center, Washington.
Urology. 1988 Sep;32(3):236-40. doi: 10.1016/0090-4295(88)90391-3.
We describe an experimental model of bacterial epididymitis in New Zealand white rabbits. Inoculation of 10(7) colony-forming units of Escherichia coli in a retrograde fashion into the vas deferens reliably produced clinical, bacteriologic, and pathologic epididymitis. Inflammation was maximum at two weeks and subsided by one month without treatment. E. coli could be reisolated from the epididymides for up to two weeks post inoculation. We detected loss of spermatogenesis in both the ipsilateral and contralateral testes and the appearance of antisperm antibodies subsequent to the infection in some animals. There were 2 cases (11%) of histologic bilateral epididymitis after unilateral inoculation; one of these had bilateral clinical epididymitis with E. coli recovered from both epididymides at two weeks.
我们描述了一种新西兰白兔细菌性附睾炎的实验模型。以逆行方式将10⁷个大肠杆菌菌落形成单位接种到输精管中，可可靠地引发临床、细菌学和病理学附睾炎。炎症在两周时最为严重，未经治疗的情况下一个月后消退。接种后长达两周，均可从附睾中再次分离出大肠杆菌。我们检测到部分动物在感染后同侧和对侧睾丸均出现精子发生丧失以及抗精子抗体。单侧接种后有2例（11%）出现组织学双侧附睾炎；其中1例在两周时双侧出现临床附睾炎，且双侧附睾均培养出大肠杆菌。
