van der Heide S, Niemeijer N R, Hovenga H, de Monchy J G, Dubois A E, Kauffman H F
Department of Allergology, University Hospital Groningen, The Netherlands.
Allergy. 1998 Apr;53(4):426-30. doi: 10.1111/j.1398-9995.1998.tb03917.x.
The prevalence of sensitization to the storage mites Acarus siro (AS), Tyrophagus putrescentiae (TP), and Lepidoglyphus destructor (LD) was studied in 250 sera of patients with different degrees of sensitization to the house-dust mite Dermatophagoides pteronyssinus (DP) by measuring IgE binding to extracts of the storage mites. Additionally, allergenic cross-reactivity between DP and the storage mite species was studied by RAST inhibition with five individual sera (and a pool of these sera) with moderate IgE levels to all three storage mites and to DP. Increased serum IgE to storage mites was found in 46% of the 200 patients sensitized to DP. Increased prevalence rates of IgE titers to storage mites were associated with higher IgE levels to DP. In 50 sera without sensitization to DP, only five sera showed increased IgE to one of the storage mites. Extracts of TP almost completely inhibited the IgE binding to AS, and vice versa. DP inhibited IgE binding to all storage mites up to 60%, whereas IgE binding to DP was only minimally inhibited by extracts of storage mites. In conclusion, cosensitization to storage mites is a frequent finding in patients sensitized to DP. Although this is largely the result of cross-reactivity between different mite species, it may nevertheless be of clinical significance in patients exposed to storage mites.
通过检测与仓储螨提取物的IgE结合情况，研究了250例对屋尘螨粉尘螨（DP）有不同程度致敏的患者血清中对仓储螨腐食酪螨（TP）、粗脚粉螨（AS）和嗜卷书虱（LD）的致敏率。此外，通过对5份对所有三种仓储螨和DP均有中度IgE水平的个体血清（以及这些血清的混合样本）进行RAST抑制试验，研究了DP与仓储螨物种之间的变应原交叉反应性。在200例对DP致敏的患者中，46%发现血清中针对仓储螨的IgE升高。针对仓储螨的IgE滴度患病率增加与针对DP的更高IgE水平相关。在50份未对DP致敏的血清中，只有5份血清显示针对其中一种仓储螨的IgE升高。TP提取物几乎完全抑制了IgE与AS的结合，反之亦然。DP抑制IgE与所有仓储螨的结合达60%，而仓储螨提取物对IgE与DP的结合仅有轻微抑制作用。总之，对仓储螨的共同致敏在对DP致敏的患者中很常见。虽然这在很大程度上是不同螨类物种之间交叉反应的结果，但对于接触仓储螨的患者而言，这可能仍具有临床意义。
