未使用降脂药物的非洲黑人中的血脂异常
Lipid disorders among Black Africans non-users of lipid-lowering medication.
作者信息
Borgo Mariana Veronez, Baldo Marcelo Perim, Alvim Rafael de Oliveira, Zaniqueli Divanei, Capingana Daniel Pires, Magalhães Pedro, Silva Amilcar Bernardo da, Oliosa Polyana Romano, Sartório Carmem Luiza, Mill José Geraldo
机构信息
Programa de Pós-Graduação em Saúde Coletiva, Universidade Federal do Espírito Santo (UFES), Vitória, ES, Brasil.
Departamento de Fisiopatologia, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, MG, Brasil.
出版信息
Arch Endocrinol Metab. 2018 Oct;62(5):552-559. doi: 10.20945/2359-3997000000076.
OBJECTIVE
Angola is a sub-Saharan African country where the population has scarce access to lipidlowering medication. We sought to determine the frequency of lipid disorders among Angolan nonusers of lipid-lowering medication.
MATERIAL AND METHODS
A cross-sectional descriptive study was carried out in a sample of 604 workers from the public sector. Blood pressure and anthropometric data were measured along with biochemical parameters including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). LDL-C to HDL-C ratio (LDL-C/HDL-C) was obtained from LDL-C and HDL-C levels.
RESULTS
High frequencies of elevated blood pressure (44.8%), metabolic syndrome (20.2%), increased TC (39.2%) and increased LDL-C (19.3%) were found. Low HDL-C was more frequent in women (62.4% vs. 36.1%, p < 0.001). Isolated hypercholesterolemia was more frequent in men (9.6% vs. 2.5%, p < 0.001). Among men TC, TG, LDL-C and LDL-C/HDL-C ratio were higher and HDL-C was lower in obese than in low-weight and normal-weight participants. Among women TC, TG, LDL-C and LDL-C/HDL-C ratio were higher in obese than in normal-weight participants. Significant linear trend of increasing TC and LDL-C levels as age increased was detected for both genders (p for trend < 0.05).
CONCLUSION
The results of our study showed a high frequency of lipid disorders in Angolan non-users of lipid-lowering medication.
目的
安哥拉是撒哈拉以南非洲的一个国家，该国人口难以获得降脂药物。我们试图确定安哥拉未使用降脂药物人群中脂质紊乱的发生率。
材料与方法
对604名公共部门工作人员的样本进行了横断面描述性研究。测量了血压、人体测量数据以及包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）在内的生化参数。LDL-C与HDL-C的比值（LDL-C/HDL-C）由LDL-C和HDL-C水平得出。
结果
发现高血压（44.8%）、代谢综合征（20.2%）、TC升高（39.2%）和LDL-C升高（19.3%）的发生率较高。女性HDL-C低更为常见（62.4%对36.1%，p<0.001）。男性单纯高胆固醇血症更为常见（9.6%对2.5%，p<0.001）。在男性中，肥胖者的TC、TG、LDL-C和LDL-C/HDL-C比值高于低体重和正常体重参与者，HDL-C则较低。在女性中，肥胖者的TC、TG、LDL-C和LDL-C/HDL-C比值高于正常体重参与者。检测到两性TC和LDL-C水平均随年龄增加呈显著线性趋势（趋势p<0.05）。
结论
我们的研究结果显示，安哥拉未使用降脂药物人群中脂质紊乱的发生率较高。
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