越南北方非酒精饮料中10种邻苯二甲酸酯检测的样品制备优化
Optimization of Sample Preparation for Detection of 10 Phthalates in Non-Alcoholic Beverages in Northern Vietnam.
作者信息
Tran-Lam Thanh-Thien, Dao Yen Hai, Nguyen Duong Thanh, Ma Hoi Kim, Pham Trung Quoc, Le Giang Truong
机构信息
Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam.
University of Science, Vietnam National University HCMC, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 720400, Vietnam.
出版信息
Toxics. 2018 Nov 19;6(4):69. doi: 10.3390/toxics6040069.
A novel method was developed for the sensitive, cheap and fast quantitation of 10 phthalates in non-alcoholic beverages by liquid⁻liquid extraction (LLE) combined with gas chromatography tandem mass spectrometry (GC-MS/MS). The best results were obtained when -hexane was used as extraction solvent. A central composite design (CCD) was applied to select the most appreciated operating condition. The method performance was evaluated according to the SANTE/11945/2015 guidelines and was linear in the 0.1 to 200 µg/L range for 10 phthalate compounds, with ² > 0.996 and individual residuals <15%. Repeatability (RSD), within-laboratory reproducibility (RSD), and the trueness range were from 2.7 to 9.1%, from 3.4 to 14.3% and from 91.5 to 118.1%, respectively. The limit of detection (LOD) was between 0.5 to 1.0 ng/L and the limit of quantitation (LOQ) was between 1.5 to 3.0 ng/L for all 10 compounds. The developed method was successfully applied to the analysis of non-alcoholic beverages.
开发了一种新方法，通过液液萃取（LLE）结合气相色谱串联质谱（GC-MS/MS）对非酒精饮料中的10种邻苯二甲酸酯进行灵敏、廉价且快速的定量分析。使用正己烷作为萃取溶剂时获得了最佳结果。采用中心复合设计（CCD）来选择最适宜的操作条件。根据SANTE/11945/2015指南对该方法的性能进行了评估，10种邻苯二甲酸酯化合物在0.1至200μg/L范围内呈线性，R²>0.996，单个残差<15%。重复性（RSD）、实验室内再现性（RSD）和准确性范围分别为2.7%至9.1%、3.4%至14.3%和91.5%至118.1%。所有10种化合物的检测限（LOD）在0.5至1.0 ng/L之间，定量限（LOQ）在1.5至3.0 ng/L之间。所开发的方法成功应用于非酒精饮料的分析。
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