Department of Gastroenterology, Changhai Hospital, Shanghai, 200433, China.
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
BMC Med. 2018 Nov 22;16(1):214. doi: 10.1186/s12916-018-1215-3.
Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, with increasing incidence. The mortality rate of pancreatic cancer is rising rapidly, and is projected to be the second most common of all malignant tumors by 2030. However, the diagnosis and therapy of pancreatic cancer remain a formidable challenge. Recently, enormous efforts have been made to develop several new methods for the early diagnosis and treatment of pancreatic cancer. We briefly introduce the most groundbreaking advances in pancreatic cancer diagnosis and clinical treatment strategies over the past 15 years, including surgery, chemotherapy, endoscopic therapy, immunotherapy and personalized medicine. The signaling pathways that are altered in the progression of pancreatic cancer, which may be used as therapeutic targets, are also discussed.
胰腺癌是美国第四大癌症相关死亡原因，其发病率呈上升趋势。胰腺癌的死亡率正在迅速上升，预计到 2030 年将成为所有恶性肿瘤中第二常见的癌症。然而，胰腺癌的诊断和治疗仍然是一个巨大的挑战。最近，人们做出了巨大的努力，开发了几种新的方法来早期诊断和治疗胰腺癌。我们简要介绍了过去 15 年来在胰腺癌诊断和临床治疗策略方面最具突破性的进展，包括手术、化疗、内镜治疗、免疫治疗和个性化医学。还讨论了在胰腺癌进展中改变的信号通路，这些信号通路可能被用作治疗靶点。
