Ipsen H, Schwartz B, Wihl J A, Petersen B N, Munch E P, Janniche H, Løwenstein H
ALK Research, Hørsholm, Denmark.
Allergy. 1988 Jul;43(5):370-7. doi: 10.1111/j.1398-9995.1988.tb00431.x.
Patients allergic to pollen from alder, birch and hazel were hyposensitized during a 3-year period with either birch pollen extract alone (n = 24) or a mixture of one or more of alder, birch and hazel pollen extracts (n = 27). The effect of the treatment was evaluated by RAST and tandem crossed-radioimmunoelectrophoresis (tandem-CRIE). The patient' specific IgE response to the major allergens of alder (Aln g I), birch (Bet v I) and hazel (Cor a I and Cor a II), as measured by tandem-CRIE, and the total specific IgE response, measured by RAST, decreased significantly (Pc less than 0.05) during immunotherapy, irrespective of the extract used during the treatment. There was no significant difference (Pc less than 0.05) between the two treatment groups. The results obtained indicate either that birch pollen extract alone is adequate in the treatment of the studied patient group or the patients had been sensitized towards birch pollen alone.
对桤木、桦树和榛树花粉过敏的患者在3年期间接受了低敏治疗，其中一组单独使用桦树花粉提取物（n = 24），另一组使用桤木、桦树和榛树花粉提取物中的一种或多种的混合物（n = 27）。通过放射性变应原吸附试验（RAST）和串联交叉放射免疫电泳（tandem-CRIE）评估治疗效果。通过串联交叉放射免疫电泳测量患者对桤木（Aln g I）、桦树（Bet v I）和榛树（Cor a I和Cor a II）主要过敏原的特异性IgE反应，以及通过放射性变应原吸附试验测量的总特异性IgE反应，在免疫治疗期间均显著降低（P<0.05），无论治疗期间使用何种提取物。两个治疗组之间无显著差异（P<0.05）。所得结果表明，要么单独使用桦树花粉提取物就足以治疗所研究的患者组，要么患者仅对桦树花粉致敏。
