Möller C, Dreborg S, Einarsson R
Department of Paediatrics, Universities of Umeå, Sweden.
Clin Allergy. 1987 Nov;17(6):551-62. doi: 10.1111/j.1365-2222.1987.tb02051.x.
Thirty-nine children with birch pollinosis were given immunotherapy (IT) for 3 years with a purified, characterized and biologically standardized pollen preparation made from either birch or a mixture of birch, alder and hazel. Levels of IgE antibodies against birch, alder and oak increased early during IT (P less than 0.01) and then decreased below the initial level (P less than 0.01). Birch-specific IgG antibodies also increased (P less than 0.01) but not as rapidly as birch-specific IgE antibodies and the levels remained increased throughout IT. There were only weak correlations between immunochemical findings before IT or during early IT on one hand and the improvement during IT on the other hand. The ratio birch-specific IgG:IgE after 1.5 and 2.5 years of IT correlated with symptom scores the following season (P less than 0.01). In 60% of the children below 13 years of age, new IgE specificities developed during IT as demonstrated with crossed radioimmunoelectrophoresis. No such new IgE specificities were found in older children. These 'new sensitivities' did not appear to have any clinical implication.
39名患有桦树花粉症的儿童接受了为期3年的免疫疗法（IT），使用的是由桦树或桦树、桤木和榛树的混合物制成的纯化、特性明确且生物标准化的花粉制剂。在免疫疗法早期，针对桦树、桤木和橡树的IgE抗体水平升高（P<0.01），随后降至初始水平以下（P<0.01）。桦树特异性IgG抗体也有所增加（P<0.01），但不如桦树特异性IgE抗体增加迅速，且在整个免疫疗法期间水平持续升高。一方面，免疫疗法前或早期免疫疗法期间的免疫化学结果与另一方面免疫疗法期间的改善之间仅有微弱的相关性。免疫疗法1.5年和2.5年后桦树特异性IgG:IgE的比值与下一季的症状评分相关（P<0.01）。通过交叉放射免疫电泳显示，60%的13岁以下儿童在免疫疗法期间出现了新的IgE特异性。在年龄较大的儿童中未发现此类新的IgE特异性。这些“新敏感性”似乎没有任何临床意义。
