Wood A J, Moir D C, Campbell C, Davidson J F, Gallon S C, Henney E, McAllion S
Br Med J. 1974 Feb 23;1(5903):305-7. doi: 10.1136/bmj.1.5903.305.
Hospital-based drug monitoring facilities have been used to investigate the frequency of perceptual disturbances in inpatients receiving pentazocine and the occurrence of dependence upon this drug after discharge from hospital. A pilot study was carried out in which seven out of 70 hospital inpatients receiving pentazocine reported such episodes, while in a prospective study, 9 out of 132 patients receiving pentazocine and 1 out of 112 receiving cyclimorph, dihydrocodeine, or pethidine reported their occurrence. A total of 135 patients who received pentazocine for disorders likely to require longterm analgesia were followed up for six months after their discharge from hospital. 24 had received pentazocine after discharge; two required an increase in dosage and four expressed a preference for pentazocine.
以医院为基础的药物监测机构已被用于调查接受喷他佐辛的住院患者感知障碍的发生频率以及出院后对该药物产生依赖的情况。开展了一项初步研究，在70名接受喷他佐辛的住院患者中，有7人报告了此类发作，而在一项前瞻性研究中，132名接受喷他佐辛的患者中有9人以及112名接受环丁啡、二氢可待因或哌替啶的患者中有1人报告了此类发作。共有135名因可能需要长期镇痛的病症而接受喷他佐辛治疗的患者在出院后接受了6个月的随访。24人出院后仍在使用喷他佐辛；2人需要增加剂量，4人表示更倾向于使用喷他佐辛。
