放射治疗与免疫治疗——癌症治疗中的一种潜在联合疗法。
Radiation therapy and immunotherapy-a potential combination in cancer treatment.
作者信息
Asna N, Livoff A, Batash R, Debbi R, Schaffer P, Rivkind T, Schaffer M
机构信息
Department of Oncology, Barzilai Medical Center, Ashkelon, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Department of Pathology, Barzilai Medical Center, Ashkelon, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
出版信息
Curr Oncol. 2018 Oct;25(5):e454-e460. doi: 10.3747/co.25.4002. Epub 2018 Oct 31.
Abstract
BACKGROUND
Radiation therapy (rt) is a longstanding treatment modality for cancer. In addition, immune checkpoint blockade has been a significant development in the field of immunotherapy, modifying key immunosuppressive pathways of cancer cells.
METHODS
The aim of the present work was to review current concepts of rt and immunotherapy synergism, the abscopal effect, and the molecular effects of rt in the tumour microenvironment, its influence on immune stimulation, and potential clinical outcomes that might evolve from ongoing studies. We also discuss potential predictors of clinical response.
RESULTS
Up-to-date literature concerning the mechanisms, interactions, and latest knowledge about rt and immunotherapy was reviewed and summarized, and is presented here.
CONCLUSIONS
The possibility of using hyperfractionated rt to combine an abscopal effect with the enhanced effect of immune treatment using checkpoint blockade is a very promising method for future tumour treatments.
摘要
背景
放射治疗（RT）是一种长期用于癌症治疗的方式。此外，免疫检查点阻断已成为免疫治疗领域的一项重大进展，它改变了癌细胞关键的免疫抑制途径。
方法
本研究的目的是回顾当前关于放射治疗与免疫治疗协同作用、远隔效应以及放射治疗在肿瘤微环境中的分子效应、其对免疫刺激的影响，以及正在进行的研究所可能产生的潜在临床结果的概念。我们还讨论了临床反应的潜在预测因素。
结果
对有关放射治疗与免疫治疗的机制、相互作用及最新知识的最新文献进行了综述和总结，并在此呈现。
结论
使用超分割放射治疗将远隔效应与使用检查点阻断的免疫治疗增强效应相结合，对于未来肿瘤治疗而言是一种非常有前景的方法。
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