Hu Zishuo I, McArthur Heather L, Ho Alice Y
Icahn School of Medicine, Mount Sinai Health System, New York, NY USA.
Department of Medicine, Cedars-Sinai Medical Center, Breast Oncology, Los Angeles, CA USA.
Curr Breast Cancer Rep. 2017;9(1):45-51. doi: 10.1007/s12609-017-0234-y. Epub 2017 Mar 2.
The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor effects. Over the past 50 years, reports on the abscopal effect arising from conventional radiation have been relatively rare. However, with the continued development and use of immunotherapy strategies incorporating radiotherapy with targeted immunomodulators and immune checkpoint blockade, the abscopal effect is becoming increasingly relevant in less immunogenic tumors such as breast cancer. Here, we review the mechanism of the abscopal effect, the current preclinical and clinical data, and the application of the abscopal effect in designing clinical trials of immunotherapy combined with radiotherapy in breast cancer.
远隔效应是指局部辐射引发全身抗肿瘤效应的能力。在过去50年里，关于传统辐射产生远隔效应的报道相对较少。然而，随着将放疗与靶向免疫调节剂及免疫检查点阻断相结合的免疫治疗策略的不断发展和应用，远隔效应在乳腺癌等免疫原性较低的肿瘤中变得越来越重要。在此，我们综述远隔效应的机制、当前的临床前和临床数据，以及远隔效应在设计乳腺癌免疫治疗联合放疗临床试验中的应用。
