Tham Elizabeth Huiwen, Loo Evelyn Xiu Ling, Zhu Yanan, Shek Lynette Pei-Chi
Khoo Teck Puat-National University Children's Medical Institute, National University Health System (NUHS), Singapore, Singapore,
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore,
Int Arch Allergy Immunol. 2019;178(2):128-140. doi: 10.1159/000494129. Epub 2018 Nov 22.
Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from less affluent countries with lower allergy prevalence tend to have a lower prevalence of allergic disorders compared to native-born residents of the more affluent host country. The patterns of allergic disease prevalence also differ between first- and second-generation migrants. The timing of migration in relation to birth, age at migration, and duration of residence in the host country also influence one's atopic risk. A complex interplay of multiple environmental, socioeconomic, and cultural factors is likely responsible for these observed differences. Further research into the roles of various risk factors in modulating differences in allergic disease prevalence between migrant and native populations will enhance our understanding of the complex gene-environment interactions involved in the pathogenesis of allergic disorders.
对移民人群的研究为调查环境因素在过敏性疾病发病机制中的作用提供了重要机会。在生活在同一地理位置的移民和本地出生的人群之间，已观察到过敏患病率存在差异。与较富裕东道国的本地出生居民相比，从过敏患病率较低的较不富裕国家移民来的移民往往过敏性疾病患病率较低。第一代和第二代移民的过敏性疾病患病率模式也有所不同。与出生相关的移民时间、移民时的年龄以及在东道国的居住时间也会影响一个人的特应性风险。多种环境、社会经济和文化因素之间复杂的相互作用可能是造成这些观察到的差异的原因。进一步研究各种风险因素在调节移民和本地人群过敏性疾病患病率差异方面的作用，将增进我们对过敏性疾病发病机制中复杂的基因-环境相互作用的理解。
