Polliack A, Naparstek E, Eldor A, Ben Zvi A, Ben Bassat H, Zlotnick A
Am J Hematol. 1977;3:153-63. doi: 10.1002/ajh.2830030206.
The development of lymphocytic leukemia with a rapidly fatal clinical course is reported in a patient with kappa light-chain multiple myeloma treated with alkeran. The leukemic cells lacked the ultrastructural features of plasma cells but bore readily detectable B-cell markers and resembled lymphocytes under the light, transmission, and scanning electron microscopes. The leukemic phase is perhaps best defined as lymphocytic and probably represents a variant of plasma cell leukemia, in which the cells showed a degree of dedifferentiation from plasma cells to B lymphocytes. The possible relation between these 2 proliferative processes is discussed and the nature of leukemias developing in cases of plasma cell myeloma is briefly reviewed.
本文报道了1例接受美法仑治疗的κ轻链多发性骨髓瘤患者发生临床病程迅速致命的淋巴细胞白血病。白血病细胞缺乏浆细胞的超微结构特征，但具有易于检测到的B细胞标志物，在光学显微镜、透射电子显微镜和扫描电子显微镜下类似于淋巴细胞。白血病期或许最好定义为淋巴细胞性，可能代表浆细胞白血病的一种变异型，其中细胞表现出从浆细胞到B淋巴细胞的一定程度的去分化。讨论了这两种增殖过程之间的可能关系，并简要回顾了浆细胞骨髓瘤病例中发生的白血病的性质。
