Department of Parasitology, Faculty of Science, Charles University, BIOCEV, Vestec, 252 50, Czech Republic.
Department of Zoology, Faculty of Science, Charles University, Prague, 128 43, Czech Republic.
Trends Microbiol. 2019 Feb;27(2):96-104. doi: 10.1016/j.tim.2018.10.005. Epub 2018 Nov 19.
Arguments based on cell energetics favour the view that a mitochondrion capable of oxidative phosphorylation was a prerequisite for the evolution of other features of the eukaryotic cell, including increased volume, genome size and, eventually, phagotrophy. Contrary to this we argue that: (i) extant amitochondriate eukaryotes possess voluminous phagotrophic cells with large genomes; (ii) picoeukaryotes demonstrate that phagotrophy is feasible at prokaryotic cell sizes; and (iii) the assumption that evolution of complex features requires extra ATP, often mentioned in this context, is unfounded and should not be used in such considerations. We claim that the diversity of cell organisations and functions observed today in eukaryotes gives no reason to postulate that a mitochondrion must have preceded phagocytosis in eukaryogenesis.
基于细胞能量学的观点认为，能够进行氧化磷酸化的线粒体是真核细胞其他特征进化的先决条件，包括体积增大、基因组增大，最终还包括吞噬作用。与这一观点相反，我们认为：（i）现存的无线粒体真核生物拥有具有大基因组的巨大吞噬细胞；（ii）微微型真核生物证明了吞噬作用在原核细胞大小下是可行的；（iii）在这种情况下经常提到的进化复杂特征需要额外的 ATP 的假设是没有根据的，不应该在这种考虑中使用。我们声称，真核生物中今天观察到的细胞组织和功能的多样性并没有理由假设线粒体必须在真核生物发生之前就已经存在于吞噬作用之前。
