299例非霍奇金淋巴瘤及相关白血病的形态学和免疫表面标志物研究。
A morphologic and immunologic surface marker study of 299 cases of non-Hodgkin lymphomas and related leukemias.
作者信息
Lukes R J, Taylor C R, Parker J W, Lincoln T L, Pattengale P K, Tindle B H
出版信息
Am J Pathol. 1978 Feb;90(2):461-86.
This study relateds the cytologic types of the classification of malignant lymphoma of Lukes and Collins to the results of immunologic surface marker studies as part of a systematic multiparameter study of 299 cases of non-Hodgkin lymphomas. The results support the hypothesis that malignant lymphomas are neoplasms of the immune system and involve the B- and T-cell systems and, rarely, histiocytes. The morphologic features of the cytologic types of Lukes and Collins are predictive of the subtypes of lymphoma and considerably more effective than the immunologic surface marker techniques in identifying homogeneous groups. There are considerable methodologic and interpretive problems that are evaluated in detail. The verification of the B- and T-cell subtypes of the Lukes and Collins classification indicates that the time has come to change from the terminology and classification of lymphomas of the past to a modern immunologic approach.
作为对299例非霍奇金淋巴瘤进行系统多参数研究的一部分，本研究将卢克斯和柯林斯恶性淋巴瘤分类的细胞学类型与免疫表面标志物研究结果相关联。结果支持了这样一种假说，即恶性淋巴瘤是免疫系统的肿瘤，涉及B细胞和T细胞系统，很少涉及组织细胞。卢克斯和柯林斯细胞学类型的形态学特征可预测淋巴瘤的亚型，并且在识别同质群体方面比免疫表面标志物技术有效得多。存在相当多的方法学和解释性问题，对此进行了详细评估。对卢克斯和柯林斯分类中B细胞和T细胞亚型的验证表明，从过去淋巴瘤的术语和分类转变为现代免疫方法的时候已经到来。
Zotero 插件