Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering & Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya (UPC), Barcelona, 08019, Spain.
Bristol Dental School, University of Bristol, Bristol, BS1 2LY, UK.
Adv Healthc Mater. 2019 Jan;8(1):e1801103. doi: 10.1002/adhm.201801103. Epub 2018 Nov 22.
In biomaterials science, it is nowadays well accepted that improving the biointegration of dental and orthopedic implants with surrounding tissues is a major goal. However, implant surfaces that support osteointegration may also favor colonization of bacterial cells. Infection of biomaterials and subsequent biofilm formation can have devastating effects and reduce patient quality of life, representing an emerging concern in healthcare. Conversely, efforts toward inhibiting bacterial colonization may impair biomaterial-tissue integration. Therefore, to improve the long-term success of medical implants, biomaterial surfaces should ideally discourage the attachment of bacteria without affecting eukaryotic cell functions. However, most current strategies seldom investigate a combined goal. This work reviews recent strategies of surface modification to simultaneously address implant biointegration while mitigating bacterial infections. To this end, two emerging solutions are considered, multifunctional chemical coatings and nanotopographical features.
在生物材料科学领域，人们现在普遍认为，提高牙科和骨科植入物与周围组织的生物整合性是主要目标。然而，支持骨整合的植入物表面也可能有利于细菌细胞的定植。生物材料的感染和随后的生物膜形成可能会产生破坏性的影响，并降低患者的生活质量，这是医疗保健中一个新出现的问题。相反，抑制细菌定植的努力可能会损害生物材料与组织的整合。因此，为了提高医疗植入物的长期成功率，生物材料表面应理想地阻止细菌附着，而不影响真核细胞的功能。然而，大多数当前的策略很少同时考虑到这一目标。这项工作综述了最近的表面改性策略，以同时解决植入物的生物整合和减轻细菌感染的问题。为此，考虑了两种新兴的解决方案，多功能化学涂层和纳米形貌特征。
