Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.
Department of Obstetrics, Gynecology and Gynecological Oncology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Ujejskiego 75, 85-168 Bydgoszcz, Poland.
Nutrients. 2018 Nov 21;10(11):1813. doi: 10.3390/nu10111813.
Resveratrol (RV) is a natural non-flavonoid polyphenol and phytoalexin produced by a number of plants such as peanuts, grapes, red wine and berries. Numerous in vitro studies have shown promising results of resveratrol usage as antioxidant, antiplatelet or anti-inflammatory agent. Beneficial effects of resveratrol activity probably result from its ability to purify the body from ROS (reactive oxygen species), inhibition of COX (cyclooxygenase) and activation of many anti-inflammatory pathways. Administration of the polyphenol has a potential to slow down the development of CVD (cardiovascular disease) by influencing on certain risk factors such as development of diabetes or atherosclerosis. Resveratrol induced an increase in Sirtuin-1 level, which by disrupting the TLR4/NF-κB/STAT signal cascade (toll-like receptor 4/nuclear factor κ-light-chain enhancer of activated B cells/signal transducer and activator of transcription) reduces production of cytokines in activated microglia. Resveratrol caused an attenuation of macrophage/mast cell-derived pro-inflammatory factors such as PAF (platelet-activating factor), TNF-α (tumour necrosis factor-α and histamine. Endothelial and anti-oxidative effect of resveratrol may contribute to better outcomes in stroke management. By increasing BDNF (brain-derived neurotrophic factor) serum concentration and inducing NOS-3 (nitric oxide synthase-3) activity resveratrol may have possible therapeutical effects on cognitive impairments and dementias especially in those characterized by defective cerebrovascular blood flow.
白藜芦醇（RV）是一种天然的非黄酮多酚和植物抗毒素，由许多植物如花生、葡萄、红酒和浆果产生。大量的体外研究表明，白藜芦醇作为抗氧化剂、抗血小板或抗炎剂的使用具有有前景的效果。白藜芦醇活性的有益效果可能源于其清除 ROS（活性氧）、抑制 COX（环氧化酶）和激活许多抗炎途径的能力。多酚的给药通过影响某些危险因素，如糖尿病或动脉粥样硬化的发展，具有减缓 CVD（心血管疾病）发展的潜力。白藜芦醇诱导 Sirtuin-1 水平增加，通过破坏 TLR4/NF-κB/STAT 信号级联（toll-like receptor 4/nuclear factor κ-light-chain enhancer of activated B cells/signal transducer and activator of transcription）减少激活的小胶质细胞中细胞因子的产生。白藜芦醇引起巨噬细胞/肥大细胞衍生的促炎因子如 PAF（血小板激活因子）、TNF-α（肿瘤坏死因子-α和组胺的衰减。白藜芦醇的内皮和抗氧化作用可能有助于改善中风管理的结果。通过增加 BDNF（脑源性神经营养因子）血清浓度并诱导 NOS-3（一氧化氮合酶-3）活性，白藜芦醇可能对认知障碍和痴呆症具有潜在的治疗作用，特别是在那些以脑血管血流缺陷为特征的情况下。
