Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
Preclinical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
Oxid Med Cell Longev. 2018 Mar 18;2018:4147320. doi: 10.1155/2018/4147320. eCollection 2018.
Stroke is a leading cause of mortality worldwide, as well as a source of long-term disabilities and huge socioeconomic costs. This study investigates the effects of resveratrol, an antioxidant supplement, on blood pressure, weight status, glucose, and lipid profile in patients who had a stroke in the last 12 months. Two hundred and twenty-eight patients were divided into three groups: group I received only allopathic treatment (control group), while groups II and III received allopathic treatment with a daily supplementation of oral resveratrol (100 and 200 mg, resp.) for 12 months. In all groups, the changes of the studied parameters were monitored at 6 and 12 months from the initial evaluation. In groups II and III, resveratrol induced significant changes ( < 0.05) in the blood pressure, body mass index, as well as all parameters of the lipid profile, and glucose (in nondiabetic patients), compared to the control group. The supplementation of the allopathic treatment with resveratrol had a beneficial effect on all monitored parameters, which serve as major risk factors for stroke.
脑卒中是全球范围内主要的致死病因之一，也是导致长期残疾和巨大社会经济成本的一个因素。本研究旨在探讨白藜芦醇（一种抗氧化补充剂）对过去 12 个月内发生脑卒中的患者的血压、体重状况、血糖和血脂谱的影响。228 名患者被分为三组：I 组仅接受传统医学治疗（对照组），而 II 组和 III 组在接受传统医学治疗的同时，每天分别补充 100 和 200mg 的白藜芦醇，持续 12 个月。在所有组中，在初始评估后 6 个月和 12 个月监测研究参数的变化。与对照组相比，II 组和 III 组的白藜芦醇使血压、体重指数以及血脂谱和血糖（在非糖尿病患者中）的所有参数均发生显著变化（<0.05）。与传统医学治疗相比，白藜芦醇的补充对所有监测到的参数都有有益的影响，这些参数是脑卒中的主要危险因素。
