通过串联三组分反应简便高效地合成高度取代的茚并[1,2-b]吡咯和苊并[1,2-b]吡咯衍生物。
A Simple and Efficient Synthesis of Highly Substituted Indeno[1,2-]pyrrole and Acenaphtho[1,2-]pyrrole Derivatives by Tandem Three-Component Reactions.
机构信息
Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China.
Nanjing Hicin Pharmaceutical Co., Ltd., Nanjing 210009, Jiangsu, China.
出版信息
Molecules. 2018 Nov 20;23(11):3031. doi: 10.3390/molecules23113031.
A green, convenient and tandem procedure for the efficient synthesis of highly substituted indeno[1,2-]pyrrole and acenaphtho[1,2-]pyrrole derivatives by domino three-component reaction of tryptamine/benzylamine, 1,3-dicarbonyl compounds and ninhydrin/ acenaphthenequinone is described. The significant features of this procedure were characterized by mild reaction conditions, high yields, operational simplicity and it being environmentally benign.
通过色胺/苄胺、1,3-二羰基化合物和邻苯二酮/苊醌的串联三组分反应，高效合成高取代的茚并[1,2-]吡咯和吖萘并[1,2-]吡咯衍生物的一种绿色、简便和串联的方法。该方法的显著特点是反应条件温和、产率高、操作简单、环境友好。
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