间质干细胞衍生血管内皮生长因子在伤口愈合过程中对角质细胞的新型非血管生成作用。
Novel non-angiogenic role for mesenchymal stem cell-derived vascular endothelial growth factor on keratinocytes during wound healing.
机构信息
Ear Science Institute Australia, Western Australia, Australia; Ear Sciences Centre, University of Western Australia, Australia.
Ear Science Institute Australia, Western Australia, Australia; Ear Sciences Centre, University of Western Australia, Australia; Centre for Cell Therapy and Regenerative Medicine, University of Western Australia, Australia.
出版信息
Cytokine Growth Factor Rev. 2018 Dec;44:69-79. doi: 10.1016/j.cytogfr.2018.11.002. Epub 2018 Nov 15.
With chronic wounds remaining a substantial healthcare issue, new therapies are sought to improve patient outcomes. Various studies have explored the benefits of promoting angiogenesis in wounds by targeting proangiogenic factors such as Vascular Endothelial Growth Factor (VEGF) family members to improve wound healing. Along similar lines, Mesenchymal Stem Cell (MSC) secretions, usually containing VEGF, have been used to improve angiogenesis in wound healing via a paracrine mechanism. Recent evidence for keratinocyte VEGF receptor expression, as well as proliferative and chemotactic responses by keratinocytes to exogenous VEGFA in vitro implies distinct non-angiogenic actions for VEGF during wound healing. In this review, we discuss the expression of VEGF family members and their receptors in keratinocytes in relation to the potential for wound healing treatments. We also explore recent findings of MSC secreted paracrine wound healing activity on keratinocytes. We report here the concept of keratinocyte wound healing responses driven by MSC-derived VEGF that is supported in the literature, providing a new mechanism for cell-free therapy of chronic wounds.
慢性伤口仍然是一个严重的医疗问题，因此人们寻求新的疗法来改善患者的治疗效果。各种研究已经探索了通过靶向血管生成因子（如血管内皮生长因子 [VEGF] 家族成员）来促进伤口血管生成，从而改善伤口愈合的益处。类似地，间充质干细胞（MSC）分泌液，通常含有 VEGF，已被用于通过旁分泌机制改善伤口愈合中的血管生成。最近的证据表明角质形成细胞表达 VEGF 受体，以及角质形成细胞对体外外源性 VEGFA 的增殖和趋化反应，这意味着 VEGF 在伤口愈合过程中具有独特的非血管生成作用。在这篇综述中，我们讨论了角质形成细胞中 VEGF 家族成员及其受体的表达与伤口愈合治疗的关系。我们还探讨了 MSC 分泌的旁分泌对角质形成细胞的伤口愈合活性的最新发现。我们在这里报告了由 MSC 衍生的 VEGF 驱动的角质形成细胞伤口愈合反应的概念，该概念得到了文献的支持，为慢性伤口的无细胞治疗提供了新的机制。
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