Smith Joseph S, Kosusnik Austin R, Mochel Jonathan P
Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.
Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.
Front Vet Sci. 2020 Mar 17;7:97. doi: 10.3389/fvets.2020.00097. eCollection 2020.
Clinical safety data for the use of gastroprotectants in hospitalized ruminants is lacking. In human patients, multiple adverse effects are possible from the use of pantoprazole including hematologic and electrolyte abnormalities as well as anaphylaxis and edema. The medical records of all hospitalized cattle, goats, and sheep administered pantoprazole over an ~5-year period were retrospectively analyzed for adverse effects. Seventy-nine eligible patients were observed. Hypomagnesemia was observed after pantoprazole administration in 10 cattle; however, no significant changes were noted when compared to baseline before pantoprazole administration. Significant changes were noted in serum indicators of hepatic and renal function; however, these represented downward trends that were most likely clinically insignificant. Anaphylaxis after pantoprazole administration was not observed; however, seven cattle displayed edema after pantoprazole administration. Veterinary clinicians should be aware of the potential for hypomagnesemia in hospitalized ruminants being administered pantoprazole and monitor patients accordingly. While these preliminary retrospective results indicate that pantoprazole may be a safe adjunctive therapy in hospitalized ruminants, additional studies are necessary to further determine the safety and toxicity of pantoprazole in ruminants.
目前缺乏关于住院反刍动物使用胃保护剂的临床安全性数据。在人类患者中，使用泮托拉唑可能会产生多种不良反应，包括血液学和电解质异常以及过敏反应和水肿。对约5年期间所有接受泮托拉唑治疗的住院牛、山羊和绵羊的病历进行回顾性分析，以评估不良反应。共观察了79例符合条件的患者。10头牛在使用泮托拉唑后出现低镁血症；然而，与使用泮托拉唑前的基线相比，未发现显著变化。肝功能和肾功能的血清指标有显著变化；然而，这些变化呈下降趋势，很可能在临床上无显著意义。未观察到使用泮托拉唑后的过敏反应；然而，7头牛在使用泮托拉唑后出现水肿。兽医临床医生应意识到接受泮托拉唑治疗的住院反刍动物有发生低镁血症的可能性，并相应地对患者进行监测。虽然这些初步的回顾性结果表明泮托拉唑在住院反刍动物中可能是一种安全的辅助治疗药物，但仍需要进一步研究以确定泮托拉唑在反刍动物中的安全性和毒性。
