Monteiro M G, Schuckit M A
Department of Psychopharmacology, Escola Paulista de Medicina, São Paulo, Brazil.
J Clin Psychiatry. 1988 Sep;49 Suppl:3-7.
This article reviews recent studies of men at high risk for the future development of alcoholism. The most promising differences between young men with and without a family history of this disorder include a decreased intensity of reaction to ethanol for sons of alcoholics compared with control subjects, a decreased amplitude of the P300 wave of the event-related potential, and a different pattern of background cortical electroencephalograms (alpha waves) for subjects at high risk for future alcoholism. The implications of these and other findings and their possible future impact on the clinical practice are discussed.
本文综述了近期对未来有酗酒高风险男性的研究。有酗酒家族史和无酗酒家族史的年轻男性之间最有前景的差异包括：与对照对象相比，酗酒者儿子对乙醇的反应强度降低；事件相关电位的P300波幅降低；未来有酗酒高风险的受试者背景皮质脑电图（阿尔法波）模式不同。文中讨论了这些及其他发现的意义以及它们未来可能对临床实践产生的影响。
