Cicero Arrigo F G, Colletti Alessandro, Fogacci Federica, Bove Marilisa, Giovannini Marina, Borghi Claudio
Department of Medical and Surgical Sciences, University of Bologna, Via Albertoni 15, 40138, Bologna, Italy.
High Blood Press Cardiovasc Prev. 2018 Dec;25(4):401-405. doi: 10.1007/s40292-018-0289-5. Epub 2018 Nov 23.
Beyond the well-known effects on blood pressure (BP) of the dietary approaches to stop hypertension (DASH) and the Mediterranean diets associated to a correct lifestyle, often a lifestyle change is not simple and can show only long-time results: in this sense, a possible support might be derived from the use of some anti-hypertensive supplements or nutraceuticals, which may provide a significant reduction in blood pressure.
We conducted a randomized, double-blind, placebo-controlled clinical trial in a group of 36 pre-hypertensive and first-degree hypertensive patients.
The treatment period with a mix of bioactive substances (BPLN, containing a donor of nitric oxide, magnesium, and vitamins) or placebo was 16-week long and was preceded by 4 weeks of diet stabilization.
At the end of the intervention, patients treated with the nutraceutical product showed a significant reduction of all morning pressure parameters and of evening systolic blood pressure, both versus the baseline and versus the group treated with placebo. These effects were maintained even after the first 16 weeks of treatment, confirming that the preliminary results were not due to simple changes in volume and do not lead to adaptation/tachyphylaxis. No patient complained of any side effects while taking the active treatment and placebo.
The tested nutraceutical composite reduces systolic and diastolic blood pressure in the medium term, leading to a significant reduction in the estimated cardiovascular risk in a sample of patients with pre-hypertension or first-degree hypertension.
除了广为人知的终止高血压膳食疗法（DASH）以及与正确生活方式相关的地中海饮食对血压的影响外，生活方式的改变往往并非易事，且可能仅在长期才能显现效果：从这个意义上讲，使用某些抗高血压补充剂或营养保健品可能会有所帮助，它们或许能显著降低血压。
我们对36名高血压前期和一级高血压患者进行了一项随机、双盲、安慰剂对照临床试验。
使用生物活性物质混合物（BPLN，含有一氧化氮供体、镁和维生素）或安慰剂的治疗期为16周，在此之前有4周的饮食稳定期。
在干预结束时，与基线相比以及与接受安慰剂治疗的组相比，接受营养保健品治疗的患者所有早晨血压参数以及夜间收缩压均显著降低。即使在治疗的前16周之后，这些效果仍然保持，证实初步结果并非由于血容量的简单变化所致，也不会导致适应性/快速减敏反应。在服用活性治疗药物和安慰剂期间，没有患者抱怨任何副作用。
经测试的营养保健品组合在中期可降低收缩压和舒张压，从而使高血压前期或一级高血压患者样本中的估计心血管风险显著降低。
