长非编码 RNA 与宫颈癌。
Long non-coding RNAs and cervical cancer.
机构信息
Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran.
Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran.
出版信息
Exp Mol Pathol. 2019 Feb;106:7-16. doi: 10.1016/j.yexmp.2018.11.010. Epub 2018 Nov 22.
Cervical cancer is determined as the second highest number of deaths factor in female cancers. Here is a need to find new biomarkers for detection and preliminary prognosis, metastasis. To find new treatment to enhance the survival of cervical cancer patients, pivotal actions are necessitated to be implemented. Long non-coding RNAs (lncRNAs) appear to be the crucial modulators in various processes and critically influence the oncogenesis. The commencement and general review actions of the following lncRNAs HOTAIR, H19, XIST, CCHE1, EBIC, MALAT1, ANRIL, LET, NEAT1, BLACAT1, UFC1, SNHG16 and SNHG20 are focused in this review article. Roles of the lncRNAs in cervical cancer in terms of prognosis and tumor progression, invasion and metastasis, apoptosis, and radio-resistance are pointed out. In this review the utilization of lncRNAs as biomarkers in cervical cancer prognosis for metastasis is discussed. An overview of this review will be useful for selection of biomarkers in diagnosis, prognosis, and targeted therapy of cervical cancer in the future.
宫颈癌是女性癌症中死亡率第二高的癌症。因此，有必要寻找新的生物标志物用于检测和初步预后、转移。为了找到新的治疗方法来提高宫颈癌患者的生存率，需要采取关键行动。长非编码 RNA（lncRNA）似乎是各种过程中的关键调节剂，并对肿瘤发生产生重大影响。本文重点关注以下 lncRNA：HOTAIR、H19、XIST、CCHE1、EBIC、MALAT1、ANRIL、LET、NEAT1、BLACAT1、UFC1、SNHG16 和 SNHG20 的起始和一般综述作用。本文指出了 lncRNA 在宫颈癌中的作用，包括预后和肿瘤进展、侵袭和转移、凋亡和放射抵抗。本文还讨论了 lncRNA 作为宫颈癌转移预后生物标志物的应用。本文的综述将有助于未来选择宫颈癌诊断、预后和靶向治疗的生物标志物。
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