Shi Dan, Zhang Cheng, Liu Xiaodong
Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University; Department of Radiation Oncology China-Japan Union Hospital of Jilin University, Changchun, China.
Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China.
J Cancer Res Ther. 2018;14(4):745-753. doi: 10.4103/jcrt.JCRT_669_17.
This is a review about long noncoding RNAs (lncRNAs) and cervical cancer, especially the crucial regulating role played by lncRNAs on cervical cancer. LncRNAs are a big family with popular investigation in the last years. LncRNAs, as its noncoding proteins, once were considered to be useless RNAs without much more concern. However, much more attention was paid with the unique relationships between lncRNAs and disease. Especially, lncRNAs were evaluated and found its modifying and regulating functions in the process of cancer development. In this review, we summarize the characteristics of certain lncRNAs which are crucial for cervical cancer, find their mechanisms, and provide more possible direction for following evaluations including the point for target treatment.
这是一篇关于长链非编码RNA（lncRNAs）与宫颈癌的综述，尤其关注lncRNAs在宫颈癌中发挥的关键调控作用。lncRNAs是一个庞大的家族，在过去几年中受到广泛研究。lncRNAs由于不编码蛋白质，曾被认为是无用的RNA而未受到太多关注。然而，随着lncRNAs与疾病之间独特关系的发现，其受到了更多关注。特别是，lncRNAs在癌症发展过程中的调节功能得到了评估和发现。在本综述中，我们总结了某些对宫颈癌至关重要的lncRNAs的特征，找出其作用机制，并为后续评估（包括靶向治疗要点）提供更多可能的方向。
