College of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Brain Res Bull. 2019 Jan;144:68-74. doi: 10.1016/j.brainresbull.2018.11.012. Epub 2018 Nov 22.
Since the metabolic disorder may be the high risk that contribute to the progress of Alzheimer's disease (AD). Overtaken of High-fat, high-glucose or high-cholesterol diet may hasten the incidence of AD in later life, due to the metabolic dysfunction. But the metabolism of lipid in brain and the exact effect of lipid to brain or to the AD's pathological remain controversial. Here we summarize correlates of lipid metabolism and AD to provide more foundation for the daily nursing of AD sensitive patients.
由于代谢紊乱可能是导致阿尔茨海默病（AD）进展的高危因素。高脂肪、高糖或高胆固醇饮食的过度摄入可能会由于代谢功能障碍而加速晚年 AD 的发病。但是大脑中的脂质代谢以及脂质对大脑或 AD 病理的确切作用仍存在争议。在这里，我们总结了脂质代谢与 AD 的相关性，为 AD 敏感患者的日常护理提供更多依据。
