Liu Qiang, Zhang Juan
CAS Key Laboratory of Brain Function and Disease and School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China,
Neurosci Bull. 2014 Apr;30(2):331-45. doi: 10.1007/s12264-013-1410-3. Epub 2014 Apr 15.
Lipids play crucial roles in cell signaling and various physiological processes, especially in the brain. Impaired lipid metabolism in the brain has been implicated in neurodegenerative diseases, such as Alzheimer's disease (AD), and other central nervous system insults. The brain contains thousands of lipid species, but the complex lipid compositional diversity and the function of each of lipid species are currently poorly understood. This review integrates current knowledge about major lipid changes with the molecular mechanisms that underlie AD pathogenesis.
脂质在细胞信号传导和各种生理过程中发挥着关键作用，尤其是在大脑中。大脑中脂质代谢受损与神经退行性疾病（如阿尔茨海默病（AD））及其他中枢神经系统损伤有关。大脑中含有数千种脂质，但目前对复杂的脂质组成多样性以及每种脂质的功能了解甚少。本综述整合了有关主要脂质变化的现有知识以及AD发病机制的分子基础。
