Department of Medical Microbiology, Laboratory of Clinical Virology, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands.
Institute of Biomedicine, University of Turku, Turku, Finland.
Antiviral Res. 2019 Jan;161:100-107. doi: 10.1016/j.antiviral.2018.11.010. Epub 2018 Nov 23.
Several research groups in Europe are active on different aspects of human picornavirus research. The AIROPico (Academia-Industry R&D Opportunities for Picornaviruses) consortium combined the disciplines of pathogenesis, diagnostics and therapy development in order to fill the gaps in our understanding of how picornaviruses cause human disease and how to combat them. AIROPico was the first EU consortium dedicated to human picornavirus research and development, and has largely accelerated and improved R&D on picornavirus biology, diagnostics and therapy. In this article, we present the progress on pathogenesis, diagnostics and treatment strategy developments for human picornaviruses resulting from the structured, translational research approach of the AIROPico consortium. We here summarize new insights in protection against infection by maternal or cross-protective antibodies, the visualisation of interactions between virus and neutralizing antibodies by cryoEM structural imaging, and the outcomes from a picornavirus-infected human 3D organoid. Progress in molecular detection and a fast typing assay for rhinovirus species are presented, as well as the identification of new compounds potentially interesting as therapeutic compounds.
欧洲的几个研究小组在人类小核糖核酸病毒研究的不同方面开展了研究。AIROPico（小核糖核酸病毒研发的学术-产业合作机会）联盟将发病机制、诊断和治疗开发方面的学科结合起来，以填补我们对小核糖核酸病毒如何引起人类疾病以及如何对抗它们的理解中的空白。AIROPico 是第一个致力于人类小核糖核酸病毒研发的欧盟联盟，它在很大程度上加速和改善了小核糖核酸病毒生物学、诊断和治疗的研发。在本文中，我们展示了 AIROPico 联盟结构化、转化研究方法在人类小核糖核酸病毒发病机制、诊断和治疗策略开发方面的进展。我们在这里总结了针对感染的保护的新见解，即母体或交叉保护抗体、通过冷冻电镜结构成像观察病毒与中和抗体之间的相互作用，以及小核糖核酸病毒感染的人类 3D 类器官的结果。介绍了分子检测方面的进展以及用于鉴定鼻病毒种的快速分型检测方法，以及确定具有治疗潜力的新型化合物。
