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成人WHO二级小脑桥脑角室管膜瘤的显微外科全切除

Microsurgical Gross Total Resection of a WHO Grade II Cerebellopontine Angle Ependymoma in an Adult.

作者信息

Sayyahmelli Sima, Ucer Melih, Baskaya Mustafa K

机构信息

Department of Neurological Surgery, University of Wisconsin Medical School, Madison, Wisconsin, United States.

出版信息

J Neurol Surg B Skull Base. 2018 Dec;79(Suppl 5):S426-S427. doi: 10.1055/s-0038-1669969. Epub 2018 Sep 25.

Abstract

Infratentorial ependymomas that arise in the fourth ventricle and extend into the cerebellopontine angle (CPA) through the foramina of Luschka are well described. However, a primary CPA location of an ependymoma is distinctly uncommon. In this video, we present a 46-year-old man with episodes of dizziness, left-sided tinnitus, imbalance, double vision, and nausea. An magnetic resonance imaging (MRI) scan of the head showed a large mass lesion centered in the CPA with heterogenous enhancement. Differential diagnosis included ependymoma, meningioma, schwannoma of the vestibular nerve, or lower cranial nerves, and choroid plexus papilloma. He underwent microsurgical gross total resection of the tumor via a retrosigmoid approach. Direct stimulation of the cranial nerves was performed throughout the case and there was no attachment of the tumor to any cranial nerve to suggest that this might be a schwannoma. The tumor encased important vasculature, including the posterior-inferior cerebellar artery. The histopathology was a grade II ependymoma. The patient tolerated the surgery well and his postoperative course was uneventful. He remained neurologically intact. He received radiation therapy and there was no recurrent or residual disease on follow-up studies. This video demonstrates important steps of the surgical approach and microsurgical resection techniques for this type of challenging tumor. The link to the video can be found at: https://youtu.be/KK-y6EYh888 .

摘要

起源于第四脑室并通过Luschka孔延伸至桥小脑角(CPA)的幕下室管膜瘤已有充分描述。然而,室管膜瘤原发于CPA的情况极为罕见。在本视频中,我们展示了一名46岁男性,他有头晕、左侧耳鸣、失衡、复视和恶心等症状。头部磁共振成像(MRI)扫描显示一个以CPA为中心的大肿块病变,呈不均匀强化。鉴别诊断包括室管膜瘤、脑膜瘤、前庭神经或低位颅神经的神经鞘瘤以及脉络丛乳头状瘤。他通过乙状窦后入路接受了肿瘤的显微手术全切。术中全程对颅神经进行了直接刺激,肿瘤未附着于任何颅神经,提示这可能不是神经鞘瘤。肿瘤包绕了重要血管,包括小脑后下动脉。组织病理学检查为II级室管膜瘤。患者对手术耐受良好,术后恢复顺利。他的神经功能保持完好。他接受了放射治疗,随访研究未发现复发或残留疾病。本视频展示了针对这类具有挑战性肿瘤的手术入路和显微手术切除技术的重要步骤。视频链接可在:https://youtu.be/KK-y6EYh888 找到。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/234e/6243230/90c6a83ed9aa/10-1055-s-0038-1669969-i180141ov-1.jpg

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