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挽救性清创、抗生素治疗及植入物保留（“DAIR”）联合局部注射特定噬菌体鸡尾酒疗法：这对一名患有复发性金黄色葡萄球菌人工关节感染的老年患者来说是一种选择吗？

Salvage Debridement, Antibiotics and Implant Retention ("DAIR") With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus Prosthetic-Joint Infection?

作者信息

Ferry Tristan, Leboucher Gilles, Fevre Cindy, Herry Yannick, Conrad Anne, Josse Jérôme, Batailler Cécile, Chidiac Christian, Medina Mathieu, Lustig S, Laurent Frédéric

机构信息

Service de Maladies Infectieuses, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, France.

Université Claude Bernard Lyon 1, France.

出版信息

Open Forum Infect Dis. 2018 Oct 24;5(11):ofy269. doi: 10.1093/ofid/ofy269. eCollection 2018 Nov.

DOI:10.1093/ofid/ofy269
PMID:30474047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6240628/
Abstract

Local injection of a bacteriophages mix during debridement, antibiotics and implant retention ("DAIR") was performed to treat a relapsing Staphylococcus chronic prosthetic joint infection (PJI). This salvage treatment was safe and associated with a clinical success. Scientific evaluation of the potential clinical benefit of bacteriophages as antibiofilm treatment in PJI is now feasible and required.

摘要

在清创、抗生素和植入物保留（“DAIR”）过程中进行噬菌体混合物局部注射，以治疗复发性金黄色葡萄球菌慢性人工关节感染（PJI）。这种挽救性治疗是安全的，且取得了临床成功。现在对噬菌体作为PJI抗生物膜治疗的潜在临床益处进行科学评估是可行且必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6db/6240628/34c853c80538/ofy26901.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6db/6240628/34c853c80538/ofy26901.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6db/6240628/34c853c80538/ofy26901.jpg

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Does Treatment Order Matter? Investigating the Ability of Bacteriophage to Augment Antibiotic Activity against Biofilms.治疗顺序重要吗？探究噬菌体增强抗生素对生物膜活性的能力。
Front Microbiol. 2018 Feb 5;9:127. doi: 10.3389/fmicb.2018.00127. eCollection 2018.
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噬菌体及其产物作为抗菌剂的再度兴起：概述
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