Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Brain Behav. 2019 Jan;9(1):e01171. doi: 10.1002/brb3.1171. Epub 2018 Nov 25.
Chronic idiopathic axonal polyneuropathy (CIAP) is a term describing axonal neuropathies of insidious onset, with slow or no progression of the disease over at least 6 months and with no etiology being identified despite appropriate investigations. We aimed to establish the prevalence of pain in patients with CIAP and investigate the impact of pain on quality of life (QoL).
All consecutive patients with CIAP attending a specialist neuropathy clinic were invited to participate. Pain was assessed via the DN4 questionnaire and the visual analogue scale (VAS). Overall Neuropathy Limitations Scale (ONLS) was used to assess the severity of neuropathy. The SF-36 questionnaire was used to measure participants' quality of life.
Fifty-five patients with CIAP were recruited (63.6% male, mean age 73.4 ± 8.7 years). Based on the DN4 questionnaire, peripheral neuropathic pain was present in 33 patients (60.0%). After having adjusted for age, gender and disease severity pain showed significant negative correlations with the energy/fatigue domain of QoL (β = -0.259, p = 0.049), with the emotional well-being domain (β = -0.368, p = 0.007) and the general health perception domain (β = -0.356, p = 0.007).
Pain is very prevalent in CIAP and is associated with poorer emotional well-being, worse general health perception, and increased fatigue.
慢性特发性轴索性神经病（CIAP）是一种描述起病隐匿的轴索性神经病的术语，疾病至少在 6 个月内缓慢或无进展，尽管进行了适当的检查，但仍未确定病因。我们旨在确定 CIAP 患者疼痛的患病率，并调查疼痛对生活质量（QoL）的影响。
邀请所有在神经科专家诊所就诊的连续 CIAP 患者参与。通过 DN4 问卷和视觉模拟量表（VAS）评估疼痛。使用总体神经病变限制量表（ONLS）评估神经病变的严重程度。使用 SF-36 问卷评估参与者的生活质量。
共招募了 55 名 CIAP 患者（63.6%为男性，平均年龄 73.4 ± 8.7 岁）。根据 DN4 问卷，33 名患者（60.0%）存在周围神经性疼痛。在调整年龄、性别和疾病严重程度后，疼痛与生活质量的能量/疲劳维度（β=-0.259，p=0.049）、情绪健康维度（β=-0.368，p=0.007）和总体健康感知维度（β=-0.356，p=0.007）呈显著负相关。
疼痛在 CIAP 中非常普遍，与较差的情绪健康、较差的总体健康感知和增加的疲劳有关。
