Department of Public Health, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.
Research Centre for Generational Health and Ageing, Faculty of Health and Medicine, The University of Newcastle, Newcastle, Australia.
Syst Rev. 2018 Nov 24;7(1):210. doi: 10.1186/s13643-018-0878-3.
In the long term, smoking cessation can decrease the risk of cancer, stroke, and heart attacks and improve overall survival. The aim of the proposed umbrella review is to summarize existing systematic reviews that assessed the effects of pharmacological interventions for smoking cessation and to evaluate the methodological quality of previously conducted systematic reviews.
Databases such as the Cochrane Library, PubMed, MEDLINE, EMBASE, CINAHIL PsychINFO Web of Science, Conference Papers Index, Scopus, and Google Scholar will be used to retrieve reviews. Systematic reviews which included only randomized control trials will be considered in this review. The primary outcome will be prolonged abstinence from smoking for a minimum of 6 months follow-up, and the secondary outcome will be point abstinence rate from smoking of less than 6 months follow-up but more than 7 days. Methodological quality of the included reviews will be assessed using the Assessment of Multiple Systematic Reviews 2 (AMSTAR 2) tool, which contains 16 domains. Two authors will screen the titles and abstracts of all reviews obtained by the search strategy, assess the full text of selected articles for inclusion, and extract data independently. The quality appraisal will be also assessed by two authors (AM, CC) independently, and Cohen's Kappa statistic will be used to assess inter-ratter agreement. The findings of the study will be narrated qualitatively to describe the effect of different pharmacotherapy on smoking cessation.
The World Health Organization recommends treatment of tobacco dependence as one approach in its comprehensive tobacco control policy. To date, many trials and systematic reviews have been conducted to assess the effectiveness of pharmacotherapy for smoking cessation. Therefore, the findings of the umbrella review will improve clinical decision-making and be used as a baseline for future studies.
PROSPERO CRD42017080906.
长期来看，戒烟可以降低癌症、中风和心脏病发作的风险，提高整体生存率。本研究旨在总结评估戒烟药物干预效果的系统评价，并评估之前进行的系统评价的方法学质量。
本研究将检索 Cochrane 图书馆、PubMed、MEDLINE、EMBASE、CINAHL PsychINFO Web of Science、会议论文索引、Scopus 和 Google Scholar 等数据库。本综述将纳入仅包含随机对照试验的系统评价。主要结局为 6 个月以上的持续戒烟，次要结局为 7 天以上但不到 6 个月的点戒烟率。采用评估多个系统评价 2 版（AMSTAR 2）工具评估纳入综述的方法学质量，该工具包含 16 个领域。两名作者将筛选检索策略获得的所有综述的标题和摘要，评估入选文章的全文，并独立提取数据。两名作者（AM、CC）将独立进行质量评估，并使用 Cohen's Kappa 统计量评估评分者间的一致性。研究结果将进行定性描述，以说明不同药物治疗对戒烟的影响。
世界卫生组织建议将烟草依赖治疗作为其综合烟草控制政策的一种方法。迄今为止，已经进行了许多试验和系统评价，以评估药物治疗戒烟的有效性。因此，该综述的结果将改善临床决策，并为未来的研究提供基线。
PROSPERO CRD42017080906。
