Department of Oncology, The First Affiliated Hospital of Xian Jiaotong University, Xi'an, 710061, Shaanxi, China.
Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA.
Cell Mol Life Sci. 2019 Mar;76(5):903-920. doi: 10.1007/s00018-018-2971-0. Epub 2018 Nov 24.
miR-424(322)/-503 are mammal-specific members of the extended miR-15/107 microRNA family. They form a co-expression network with the imprinted lncRNA H19 in tetrapods. miR-424(322)/-503 regulate fundamental cellular processes including cell cycle, epithelial-to-mesenchymal transition, hypoxia and other stress response. They control tissue differentiation (cardiomyocyte, skeletal muscle, monocyte) and remodeling (mammary gland involution), and paradoxically participate in tumor initiation and progression. Expression of miR-424(322)/-503 is governed by unique mechanisms involving sex hormones. Here, we summarize current literature and provide a primer for future endeavors.
miR-424(322)/-503 是哺乳动物特异性的扩展 miR-15/107 微 RNA 家族成员。它们与四足动物中的印迹长非编码 RNA H19 形成一个共表达网络。miR-424(322)/-503 调节包括细胞周期、上皮-间充质转化、缺氧和其他应激反应在内的基本细胞过程。它们控制组织分化（心肌细胞、骨骼肌、单核细胞）和重塑（乳腺退化），并矛盾地参与肿瘤的起始和进展。miR-424(322)/-503 的表达受涉及性激素的独特机制调控。在这里，我们总结了当前的文献，并为未来的研究提供了一个入门。
