Martinez A J, Estol C, Faris A A
University of Pittsburgh School of Medicine, Pennsylvania.
Neurol Clin. 1988 May;6(2):327-48.
The clinical and neuropathologic findings of 55 adults and 30 children who received liver transplants were reviewed. Encephalopathy was the most common clinical neurologic syndrome and was usually caused by metabolic or anoxic causes. (Alzheimer type astrocytes were present in 73 per cent of patients, and evidence of diffuse hypoxic damage was present in 40 per cent of children and 25 per cent of adults.) Cerebrovascular lesions were a common finding with infarcts or hemorrhages present in 30 per cent of patients. CNS infections were documented in 34 per cent of patients. Seizures were present in a third of patients. Central pontine myelinolysis was present in 12 per cent of patients and was more common in adults than in children. Antemortem diagnosis of neurologic complications was more often based on clinical presentation rather than specific radiologic or laboratory tests.
对55名成人和30名儿童肝移植受者的临床和神经病理学发现进行了回顾。脑病是最常见的临床神经综合征，通常由代谢或缺氧原因引起。（73%的患者存在阿尔茨海默型星形胶质细胞，40%的儿童和25%的成人存在弥漫性缺氧损伤证据。）脑血管病变是常见发现，30%的患者存在梗死或出血。34%的患者记录有中枢神经系统感染。三分之一的患者出现癫痫发作。12%的患者存在中央桥脑髓鞘溶解症，在成人中比儿童更常见。神经并发症的生前诊断更多基于临床表现而非特定的影像学或实验室检查。
