Boon A P, Adams D H, Buckels J, McMaster P
Department of Pathology, University of Birmingham.
J Clin Pathol. 1990 Feb;43(2):114-8. doi: 10.1136/jcp.43.2.114.
Nine cases of cerebral aspergillosis were identified in a series of 44 brains obtained at necropsy from patients who had undergone liver transplantation. In two of these there was dual infection with Candida albicans. The primary focus of infection was invariably in the lungs. One case of pulmonary Aspergillus infection was found with no evidence of cerebral disease. Infection tended to occur in the period soon after transplantation, was associated with high dose steroids, retransplantation, and showed a significant seasonal incidence. Neurological findings were non-specific and only two cases were diagnosed before death. Aspergillus infection soon after transplantation indicates that this organism is a considerable nosocomial hazard, particularly in the winter and spring months. Positive cultures before death are rarely obtained and antifungal treatment should be started on clinical suspicion alone.
在对44例肝移植患者尸检获得的大脑进行检查时，发现了9例脑曲霉病病例。其中2例同时感染白色念珠菌。感染的主要病灶总是在肺部。发现1例肺部曲霉菌感染，无脑部疾病证据。感染往往发生在移植后不久，与高剂量类固醇、再次移植有关，且有明显的季节性发病情况。神经学表现不具特异性，生前仅诊断出2例。移植后不久发生的曲霉感染表明，这种病原体是一种相当大的医院感染风险因素，尤其是在冬春季节。生前很少能获得阳性培养结果，应仅凭临床怀疑就开始抗真菌治疗。
