Guarino M, Stracciari A, Pazzaglia P, Sterzi R, Santilli I, Donato F, D'Alessandro R
Servizio di Neurologia, Policlinico S. Orsola-Malpighi, Bologna, Italy.
J Neurol. 1996 Feb;243(2):137-42. doi: 10.1007/BF02444004.
We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent complications were mental status changes ranging from delirium to coma and seizures. The aetiology was multifactorial, cyclosporin A neurotoxicity being the main cause. Patients with neurological complications had a higher mortality rate than those without. In our series, neurological complications represented a major medical problem with increased morbidity and mortality.
我们对199例连续接受220次肝移植的患者进行了检查，以确定移植后神经并发症的类型、发生率、病因及其预后价值。我们发现63例患者（32%）出现神经并发症，主要累及中枢神经系统。最常见的并发症是精神状态改变，从谵妄到昏迷以及癫痫发作。病因是多因素的，环孢素A神经毒性是主要原因。有神经并发症的患者死亡率高于无神经并发症的患者。在我们的研究系列中，神经并发症是一个主要的医学问题，会增加发病率和死亡率。
