Stojanović Nikola M, Radulović Niko S, Randjelović Pavle J, Laketić Darko
Nat Prod Commun. 2016 Nov;11(11):1741-1747.
This review aims at a coherent summary of the results obtained from various studies that concern analgesic-like activity of the extracts of H. preforatum L and thirteen other Hypericum L. species (Hypericaceae). Botanical origin, plant organs and extraction modes of the plant material, experimental models, routes of administration and doses used for animal treatment are summarized. Mechanisms of action and substances (and even the synergy thereof) proposed so far to be responsible for the observed activity have also been discussed. Even though St. John's wort (H. perforatum) is the most renowned plant species of this genus, it is neither the only nor the most potent one in inducing pain relief.
本综述旨在连贯总结从各种研究中获得的结果，这些研究涉及贯叶连翘及其他13种金丝桃属植物（金丝桃科）提取物的镇痛样活性。文中总结了植物材料的植物来源、植物器官和提取方式、实验模型、给药途径以及用于动物治疗的剂量。还讨论了迄今为止提出的、被认为对观察到的活性负责的作用机制和物质（甚至它们之间的协同作用）。尽管圣约翰草（贯叶连翘）是该属最著名的植物物种，但它既不是诱导疼痛缓解的唯一物种，也不是最有效的物种。
