双语能力对一位意大利文学教授认知储备的影响：其阿尔茨海默病高危人群。
Contribution of Bilingualism to Cognitive Reserve of an Italian Literature Professor at High Risk for Alzheimer's Disease.
机构信息
Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", Nuclear Medicine Unit, University of Florence, Florence, Italy.
出版信息
J Alzheimers Dis. 2018;66(4):1389-1395. doi: 10.3233/JAD-180736.
Bilingualism is an independent component of cognitive reserve that permits to delay dementia onset up to 5 years. We describe a case of a bilingual Italian man affected by mild cognitive impairment with high cognitive reserve that, despite the presence of multiple risk factors (ApoE ɛ4/ɛ4 genotype, older age, untreated Obstructive Sleep Apnea Syndrome, AD-like biomarker alterations) did not convert to Alzheimer's disease up to 5 years follow-up. The present case confirms the role of bilingualism as a strong protective factor for dementia, even in the occurrence of multiple risk factors.
双语能力是认知储备的一个独立组成部分，它可以使痴呆的发病时间延迟多达 5 年。我们描述了一例意大利双语男性轻度认知障碍患者，他具有较高的认知储备，尽管存在多种风险因素（载脂蛋白 Eɛ4/ɛ4 基因型、年龄较大、未治疗的阻塞性睡眠呼吸暂停综合征、AD 样生物标志物改变），但在 5 年的随访中并未转化为阿尔茨海默病。本病例证实了双语能力作为痴呆的一个强有力保护因素的作用，即使在多种风险因素存在的情况下也是如此。
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