双语对两种临床阿尔茨海默病变异型发病年龄的影响。
Effects of bilingualism on age at onset in two clinical Alzheimer's disease variants.
机构信息
Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.
Department of Communication Sciences and Disorders, University of Texas At Austin, Texas, USA.
出版信息
Alzheimers Dement. 2020 Dec;16(12):1704-1713. doi: 10.1002/alz.12170. Epub 2020 Sep 3.
INTRODUCTION
The effect of bilingualism on age at onset has yet to be examined within different clinical variants of Alzheimer's disease.
METHODS
We reviewed the research charts of 287 well-characterized participants with either amnestic Alzheimer's dementia or logopenic variant primary progressive aphasia (lvPPA) and identified bilingual speakers based on regular use of two or more languages and/or ability to communicate with native speakers in two or more languages. We evaluated whether bilingual speakers demonstrated a delay in age of symptom onset relative to monolingual speakers while controlling for other variables known to influence cognitive reserve.
RESULTS
A 5-year delay in age at symptom onset was observed for bilingual relative to monolingual speakers with lvPPA. This delay in onset was not observed in the amnestic Alzheimer's dementia cohort.
DISCUSSION
Bilingualism may serve as a unique cognitive reserve variable in lvPPA, but not in amnestic Alzheimer's dementia.
简介
双语对发病年龄的影响尚未在不同的阿尔茨海默病临床变异体中进行研究。
方法
我们回顾了 287 名具有明显特征的参与者的研究图表，这些参与者要么患有遗忘型阿尔茨海默病痴呆症，要么患有失语法性变异原发性进行性失语症（lvPPA），并根据定期使用两种或多种语言以及/或能够用两种或多种语言与母语人士交流来确定双语者。我们评估了双语者相对于单语者在症状发作时是否存在年龄延迟，同时控制了已知影响认知储备的其他变量。
结果
与单语者相比，患有 lvPPA 的双语者的症状发作年龄延迟了 5 年。这种发病时间的延迟在遗忘型阿尔茨海默病痴呆症队列中没有观察到。
讨论
双语可能是 lvPPA 中一种独特的认知储备变量，但在遗忘型阿尔茨海默病痴呆症中不是。
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