Gastroenterology and Liver Units, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
J Leukoc Biol. 2019 Mar;105(3):463-472. doi: 10.1002/JLB.5RU0718-276RR. Epub 2018 Nov 26.
Immune modulating treatments are often associated with immune suppression or an opposing anti-inflammatory paradigm. As such, there is a risk of exposing patients to infections and malignancies. Contrarily, eliciting only mild immune modulation can be insufficient for alleviating immune-mediated damage. Oral immunotherapy is a novel approach that uses the inherent ability of the gut immune system to generate signals that specifically suppress inflammation at affected sites, without inducing generalized immune suppression. Oral immunotherapy is being developed as a method to rebalance systemic immunity and restore balance, getting it back on track, rather than pushing the immune response too much or too little in opposing directions. Here, I review recent preclinical and clinical data examining the technique and describe its primary advantages.
免疫调节治疗通常与免疫抑制或相反的抗炎范式相关。因此，患者有感染和恶性肿瘤的风险。相反，仅引起轻度免疫调节可能不足以缓解免疫介导的损伤。口服免疫疗法是一种新方法，利用肠道免疫系统的固有能力产生信号，特异性地抑制受影响部位的炎症，而不会引起全身性免疫抑制。口服免疫疗法正被开发为一种重新平衡全身免疫并恢复平衡的方法，使其回到正轨，而不是向相反方向过度或不足地推动免疫反应。在这里，我回顾了最近检查该技术的临床前和临床数据，并描述了其主要优势。
