Mansoori Behzad, Mohammadi Ali, Shirjang Solmaz, Baradaran Behzad
a Immunology Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.
b Student Research Committee , Tabriz University of Medical Sciences , Tabriz , Iran.
Immunol Invest. 2017 Nov;46(8):880-897. doi: 10.1080/08820139.2017.1377407.
Immune cells are recruited into the tumor microenvironment and regulate anti- and pro-tumor signals. MicroRNAs (miRNAs) markedly control the immune system responses in cancer development. miRNAs that affect the immune system could be interesting targets for immunomodulation against cancer, either through the activation of effector cells or through the down-regulation of regulatory cells. Bioinformatic calculations can predict the immune system and miRNA interactions. In this review, we discuss the most recent studies about miRNA as the main regulator of recruitment and the activation of the immune system in the tumor microenvironment and finally we propose several miRNAs that could serve as therapeutic molecules in the immunotherapy of cancer.
免疫细胞被招募到肿瘤微环境中，并调节抗肿瘤和促肿瘤信号。微小RNA（miRNA）在癌症发展过程中显著控制免疫系统反应。影响免疫系统的miRNA可能是癌症免疫调节的有趣靶点，无论是通过激活效应细胞还是通过下调调节细胞来实现。生物信息学计算可以预测免疫系统与miRNA的相互作用。在本综述中，我们讨论了关于miRNA作为肿瘤微环境中免疫系统招募和激活的主要调节因子的最新研究，最后我们提出了几种可作为癌症免疫治疗中治疗分子的miRNA。
