Saso Luciano, Reza Ahmad, Ng Emily, Nguyen Kimtrang, Lin Sheng, Zhang Pangzhen, Fantozzi Paolo Junior, Armagan Guliz, Romeo Umberto, Cirillo Nicola
Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.
Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, Melbourne, VIC 3053, Australia.
Antioxidants (Basel). 2022 Apr 28;11(5):868. doi: 10.3390/antiox11050868.
Oral submucous fibrosis (OSMF) is a chronic oral potentially malignant disorder (OPMD). It is described as a scarring disease of the oral mucosa associated with excess oxidants and insufficient antioxidants. While it is becoming increasingly accepted that oxidative stress results in excessive accumulation of collagen and progressive fibrosis of the submucosal tissues, there is limited data regarding the moderation of oxidative stress to initiate or prevent OSMF. To assess the scope for mechanism-based approaches to prevent or reverse OSMF, we systematically evaluated the existing literature and investigated the role of oxidative stress in the pathogenesis and chemoprevention of OSMF. A search for relevant articles on PubMed and Scopus was undertaken using pre-defined inclusion and exclusion criteria. A total of 78 articles were selected in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The articles eligible for assessment investigated both OSMF and/or oxidative stress biomarkers or specific antioxidants. Both in vitro and human studies consistently demonstrated variations in oxidative stress biomarker levels in OSMF and revealed an increase in oxidative stress, paralleling the development of the disease. Furthermore, the use of antioxidant supplements was overall associated with an improvement in clinical outcomes. Having identified the significance of oxidative stress in OSMF and the therapeutic potential of antioxidant supplements, this scoping review highlights the need for further well-designed studies in the development of mechanism-based interventions for managing OSMF.
口腔黏膜下纤维化（OSMF）是一种慢性口腔潜在恶性疾病（OPMD）。它被描述为一种与氧化剂过量和抗氧化剂不足相关的口腔黏膜瘢痕形成疾病。虽然氧化应激导致胶原蛋白过度积累和黏膜下组织进行性纤维化这一观点越来越被接受，但关于调节氧化应激以引发或预防OSMF的数据有限。为了评估基于机制的方法预防或逆转OSMF的可能性，我们系统地评估了现有文献，并研究了氧化应激在OSMF发病机制和化学预防中的作用。使用预先定义的纳入和排除标准在PubMed和Scopus上搜索相关文章。根据系统评价和Meta分析扩展的范围综述（PRISMA-ScR）指南，共筛选出78篇文章。符合评估条件的文章研究了OSMF和/或氧化应激生物标志物或特定抗氧化剂。体外研究和人体研究均一致表明，OSMF中氧化应激生物标志物水平存在差异，并揭示氧化应激增加与疾病发展平行。此外，使用抗氧化剂补充剂总体上与临床结果改善相关。在确定氧化应激在OSMF中的重要性以及抗氧化剂补充剂的治疗潜力后，本范围综述强调需要进一步开展精心设计的研究，以开发基于机制的干预措施来管理OSMF。
