儿童慢性白血病。
Chronic leukemias of childhood.
作者信息
Altman A J
机构信息
University of Connecticut School of Medicine, Farmington.
出版信息
Pediatr Clin North Am. 1988 Aug;35(4):765-87. doi: 10.1016/s0031-3955(16)36509-9.
Chronic leukemias account for fewer than 5 per cent of childhood hematologic malignancies. The various subtypes are chronic mylocytic leukemia (adult, juvenile, and familial), chronic myelomonocytic leukemia chronic monocytic leukemia, and chronic lymphocytic leukemia. The most common of these, adult-type chronic myelocytic leukemia, is characterized by specific cytogenetic alterations; recent advances in molecular biology are linking these genetic events to the pathophysiology and course of this fascinating neoplasm.
慢性白血病在儿童血液系统恶性肿瘤中所占比例不到5%。其亚型包括慢性粒细胞白血病（成人型、青少年型和家族型）、慢性粒单核细胞白血病、慢性单核细胞白血病以及慢性淋巴细胞白血病。其中最常见的成人型慢性粒细胞白血病具有特定的细胞遗传学改变；分子生物学的最新进展正在将这些基因事件与这种迷人肿瘤的病理生理学和病程联系起来。
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