Salo Veijo T
Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Front Cell Dev Biol. 2023 Feb 3;11:1112954. doi: 10.3389/fcell.2023.1112954. eCollection 2023.
Cells store excess energy in the form of lipid droplets (LDs), a specialized sub-compartment of the endoplasmic reticulum (ER) network. The lipodystrophy protein seipin is a key player in LD biogenesis and ER-LD contact site maintenance. Recent structural and studies have started to shed light on the molecular function of seipin as a LD nucleator in early LD biogenesis, whilst new cell biological work implies a role for seipin in ER-mitochondria contact sites and calcium metabolism. In this minireview, I discuss recent insights into the molecular function of seipin.
细胞以脂滴（LDs）的形式储存多余能量，脂滴是内质网（ER）网络的一个特殊亚区室。脂肪营养不良蛋白丝氨酸蛋白酶抑制剂是脂滴生物合成和内质网-脂滴接触位点维持的关键参与者。最近的结构和研究已经开始揭示丝氨酸蛋白酶抑制剂作为早期脂滴生物合成中脂滴成核剂的分子功能，而新的细胞生物学研究表明丝氨酸蛋白酶抑制剂在内质网-线粒体接触位点和钙代谢中发挥作用。在这篇综述中，我讨论了对丝氨酸蛋白酶抑制剂分子功能的最新见解。
