Department of Health Sciences, Feevale University, ERS-239, 2755, Zip Code: 93525-075, Novo Hamburgo, Rio Grande do Sul, Brazil.
Department of Health Sciences, Feevale University, ERS-239, 2755, Zip Code: 93525-075, Novo Hamburgo, Rio Grande do Sul, Brazil.
Chemosphere. 2019 Mar;218:425-429. doi: 10.1016/j.chemosphere.2018.11.124. Epub 2018 Nov 20.
Agriculture production has been supported especially by the use of pesticides for crop protection and pest control. Although the agricultural production has been increased by pesticides use, these substances also reach non-target organisms and may become a risk to the health of farmers. Several epidemiological studies in human have investigated the association between exposure to pesticides and altered serum levels of thyroid hormones, reporting both positive and negative results. Overall, the impact of pesticides on human thyroid function is still limited.
The aim of this study was to access serum levels of free thyroxin (FT4), total triiodothyronine (TT3), thyroid-stimulating hormone (TSH), and butyrylcholinesterase (BChE) in soybean farmers in southern Brazil.
The exposed group was composed by 46 rural workers and 27 subjects not exposed to pesticides composed the control group. All subjects had blood samples collected by venipuncture in order to analyze the serum levels of FT4, TT3, TSH and BChE.
The results showed a significant decreasing in TSH and increasing in TT3 and FT4 in rural workers, compared to control group. BChE levels were lower in exposed group than in control group. The results suggest that farmers are exposed to mixtures of pesticides with endocrine disruptor properties.
农业生产特别依赖于使用农药来保护作物和防治害虫。虽然农药的使用提高了农业生产，但这些物质也会到达非目标生物，并可能对农民的健康构成威胁。一些针对人类的流行病学研究调查了接触农药与甲状腺激素血清水平改变之间的关系，报告了正反两方面的结果。总的来说，农药对人类甲状腺功能的影响仍然有限。
本研究旨在评估巴西南部大豆种植农民的血清游离甲状腺素（FT4）、总三碘甲状腺原氨酸（TT3）、促甲状腺激素（TSH）和丁酰胆碱酯酶（BChE）水平。
暴露组由 46 名农村工人和 27 名未接触农药的对照组组成。所有受试者均通过静脉采血采集血样，以分析血清 FT4、TT3、TSH 和 BChE 水平。
与对照组相比，农村工人的 TSH 显著降低，TT3 和 FT4 显著升高。暴露组的 BChE 水平低于对照组。结果提示农民接触到具有内分泌干扰特性的农药混合物。
