Goyal Laxmikant, Shah Pujan J, Yadav R N, Saigal Renu, Agarwal Abhishek, Banerjee S
Assistant Professor, Geriatric Medicine.
Senior Resident, Department of Cardiology, SGPGI, Lucknow, Uttar Pradesh.
J Assoc Physicians India. 2018 May;66(5):26-9.
To detect frequency of anemia in patients of Rheumatoid arthritis (RA) and to establish relationship between hemoglobin level and disease activity in RA.
Fifty nine patients of RA fulfilling 2010 ACR/EULAR criteria of RA having disease duration less than two years were included in the study. Haemoglobin (Hb) levels were measured. Disease activity was assessed by DAS-28 score.
Among 40/59 (67.80%) anemic cases, 22/40 (55%) patients had anaemia of chronic disease (ACD), 11/40 (27.50%) patients had Iron deficiency anemia (IDA), 3/40 (7.5%) patients had vitamin B(12) deficiency, 1/40 (2.50%) patient had folate deficiency and 3/40 (7.50%) patients had combined IDA and vitamin B(12) deficiency. Duration of disease, rheumatoid factor positivity and occurrence of erosive disease were not significantly different among anaemic and nonanaemic patients (p>0.05 for each). Mean ESR (p>0.02) and DAS-28 (p>0.001) were statistically significantly different among anaemic and nonanaemic patients. Haemoglobin level had significant negative correlation with disease activity (DAS28) in RA cases (r -0.5533, p<0.0001). Conclusion: Anemia was seen in higher frequency in RA patients. Haemoglobin had significantly negative correlation with disease activity (DAS 28) in RA. .
Anemia was seen in higher frequency in RA patients. Haemoglobin had significantly negative correlation with disease activity (DAS 28) in RA.
检测类风湿关节炎（RA）患者贫血的发生率，并建立血红蛋白水平与RA疾病活动度之间的关系。
本研究纳入了59例符合2010年美国风湿病学会（ACR）/欧洲抗风湿病联盟（EULAR）RA标准、病程小于两年的RA患者。测量血红蛋白（Hb）水平。通过疾病活动度评分（DAS-28）评估疾病活动度。
在40/59（67.80%）例贫血患者中，22/40（55%）例患者患有慢性病贫血（ACD），11/40（27.50%）例患者患有缺铁性贫血（IDA），3/40（7.5%）例患者患有维生素B12缺乏，1/40（2.50%）例患者患有叶酸缺乏，3/40（7.50%）例患者患有IDA合并维生素B12缺乏。贫血患者与非贫血患者在病程、类风湿因子阳性率及侵蚀性疾病发生率方面无显著差异（每项p>0.05）。贫血患者与非贫血患者的平均红细胞沉降率（ESR）（p>0.02）和DAS-28（p>0.001）在统计学上有显著差异。在RA病例中，血红蛋白水平与疾病活动度（DAS28）呈显著负相关（r=-0.5533，p<0.0001）。结论：RA患者贫血发生率较高。在RA中，血红蛋白与疾病活动度（DAS 28）呈显著负相关。
RA患者贫血发生率较高。在RA中，血红蛋白与疾病活动度（DAS 28）呈显著负相关。
